one room till they are big enough not to get into trouble by themselves.
Leave them plenty of water, toys and access to food  put the litter pan on
the opposite side of the room.

Make sure your child proof the room. Think of them as toddlers that are just
able to walk. they will get into everything like a child will.  Touch
everything, knock over everything.

Please ask any question the regulars will answer what we can and if we can't
will point you in the right direction.  There are a couple other groups such
as rec.pets.cats.anecdotes that always welcome new members and love to hear
about your fur balls.

When I got my Ka'Shay she is right now just over a year old.  I separated
her from the others;  who range in age from 5 years to 13 years old, till
she was about 6 months when I was out of the house.

Ps  Be ready for slave hood it is a new world and thank you for adopting

You could take a little time and "kitten proof" your house...Get rid of all
the plastic bags, fall-over hazards, and tangle hazards like string and the
like, so your kittens won't have any way to get hurt, and then you can leave
them alone without fear. You have to leave them alone when you run down to
the store for a bottle of milk anyway, and they can get hurt in those few
minutes just as easily as they can in 8 hours........

I would confine them to one room for awhile--until they are thoroughly
adjusted/acclimated to your home.  Make sure they have lots of toys (*safe*
toys with no strings or cords attached), and it's a good idea to leave a
radio on for "companionship."  Tune it at low or moderate volume to a
classical or easy-listening station.

Here's another suggestion:  Instead of adopting two kittens, why not adopt
two adult cats?  Be sure to get two cats that are already companions and not
two "separate" adoptions.  Adult cats are often harder to place than
kittens, but it would also be advantageous to you--personalities change as
kittens grow, but with adults you know more about whether they have the type
of personalities that will fit the situation you described.  Adults also do
not need as much attention as kittens, so your working hours would not be a
problem.

MaryL

We adopted two feral kittens two days ago for the same reason.  My in-laws
have a feral cat who has had three litters under their kitchen window, and
these two were from the last litter back in April.  We work long hours so we
thought they'd have each other to play with.  So far we've only seen one of
them come out of hiding in the basement room they're confined to.  They will
not use the litter box and we can't pick them up to place them in there and
show them how it's done.  Last night we found they had used their dry food
dish as a litter box, and this morning it was on the floor (at least not in
the food!).  I've seen some posts here saying to put outside dirt in the
litter box, so I'll try that tonight.  Any other suggestions?  All of the
other kittens this momma cat had have been really sweet and easily
domesticated.