I've done that - it works with some liquids and some pills (crushed),
but not all.  Actually, I try it first - human grade chunk light tuna
in water.  They prefer the juice, but the meat helps conceal any
texture in the medicine.

Hahahaha, Momo I'm having trouble typing for laughing at
the hilarious posts here! 8^P

My Luthien is on hyperthyroid meds for life.  The trick,
whether you use a pill or a syringe, is to get the thing
past where cat's tongue can get to it.

So with a pill, control the jaw, keep it well open (cat upside down on
your lap and secure in your arms, left hand (reverse this if you
are left-handed) holding upper jaw from above [not by the front,
but clawlike from each side, get behind the fangs for best leverage]
right hand holding pill in thumb and index finger, use your
right middle finger to slowly work into his mouth from the front which
he is vicelike trying to keep closed and slowly open to
the point where you can get a grip on his lower jaw, behind
the fangs so he can't wriggle out of it,
with the middle,ring and little fingers...never pull down
on the jaw directly, but lever it open).  Take your time
with this part...it is essential to the success of the procedure
and once you are sure you have the jaw secure and open,
take a look down there and mark your target.  Face up
(the cat, not you, heh), neck extended, so that you can
literally drop the pill down the long channel you see,
not to the back of the throat or on the tongue, but
even lower down, way past the tongue.

It takes aim...but once it's there, he
can't get at it till you let him close his mouth.  When it's
done, you immediately and I mean fast, close his mouth
and hold it closed around the muzzle without obstructing
the nose-breathing.  Keep holding it closed while you,
or helper strokes the still extended neck at the front,
the adam's apple area, so-to-speak, which stimulates
swallowing.  Keep doing that until you see his little tongue
slip out between his closed lips....that means he gave up
and swallowed and you can then let go and deal with
the righteous anger at that point.

This method has never taken me longer than two minutes
if I am careful and deliberate with the initial stage.  Don't
even try to drop the pill until you are sure of your grip
and position.  Stop and retry the position until you are
sure, and *then* and only then, drop the pill.  I have
never lost a pill anywhere except down a cat's throat
with this method.  The only problem is that he is less
than enamoured with it, and so the trick is to catch the
cat in the first place when he knows what's coming.
Don't take the pills out until you have him firmly in
your arms.

With a syringe, you don't need to open the mouth so wide,
but slip it past the teeth in the side pocket of his cheek,
just as if you were putting a little toothbrush back to get
the molars.  Then put it a little farther.  At that point, you
can close his mouth as in the above....again, hold it
closed, with nose-breathing unobstructed.  Obviously
it will need to be a small, 1cc syringe, so you might need
more than one, depending on the size of the dose.  Have
them all filled and ready, if necessary.  This method generally
takes at least three hands, which is why I prefer the pill
which can be done single-handedly (well, two hands, but
one person).  Don't even bother squirting until you are
secure in this position.  Once the syringe is well-situated
at the back of his mouth, squirt, in small amounts, and
stroke, watching for that little tongue sign which means
he swallowed.  Don't want him to choke, so watch for
the swallow before you squirt again.  If it's coming out
the side, the syringe is not far back enough.  When it's
all gone, release, and run for cover!

The main thing is to watch for that swallow.  If you vow
never to let go till you see that swallow, you will never
have to clean your ceiling again.

I like pills better because if you do it right, the cat
never actually tastes it at all, but is only pissed off
at the indignity of the process.

--tension

ps.  if I am not mistaken, there is a good pictorial
demonstration of the pilling method on Phil's
maxhouse website, you might want to look if
my verbal instructions aren't translating to a
picture for you.