rescue remedy is a spray that helps calm pets in stressful situations (given
to dogs a lot who are afraid of thunder)  I used it for my Eli who was
paranoid that I was always going to medicate him.  The recommendation is to
spray under the tongue, but you can put on food (which is what I did cause
there was NO way I was going to be able to spray it in his mouth)

Feliway is a pheromone spray or defuser that is a welcoming hormone.  Very
calming for a cat to be welcomed by another cat type smell.  I used this
when moving my cats to the new house.  Used in shelters, and often
recommended for inappropriate urination or scratching, cause cats won't pee
or scratch where they mark.  spray in one corner of the carrier and on any
corners the kitty might come in contact with.

Try a cloth type carrier, one that she can feel like she is in a cave like
environment.  When my cats freak out, they go for small dark spaces.  Big
plastic carriers might leave the kitty feeling very vulnerable.

Put in a cloth or towel that smells like you.  Have who ever is closest to
the kitty wear a shirt to bed and exercise in it for a couple of days.  Yuck
to you, but very comforting to the kitty.

If you can, bring her litter box, with some of her previously used litter.
(scooped or cleaned of course)  if you can't bring her box, bring some of
her litter if you can.

Kitties are creatures of habit, so if yours has something she always does do
your best to try to keep up those rituals.

I wish you well on your drive, and may the treatment be successful!

Last fall, I moved about 1400 miles and I was worried how my furry
friend would deal with the trip.

All her previous car trips (always in a carrier, as it's just not safe
to let her roam around the car while driving) were about 30 minutes and
she would cry the whole way.

I dreaded the thought of her crying for 14 hours and got some drugs from
the vet in case, but I didn't want to drug her, so I held onto them as a
last resort.

About 45 minutes into the trip, she calmed down and went to sleep.

A couple of hours into it, I stopped to give both myself and her a
break.  She wasn't too enthralled with the idea and didn't want to roam
the rest area, despite the fact that is was actually very nice (she's
been an indoor cat since I took her in at 5-6 weeks old.)

Later on, she decided she liked the comfort of her carrier when I
stopped and had to be practically dragged out of it.  I thought she
would want a drink of water, but she wasn't into it.  She had come to
prefer the comfort of her carrier, and she was perfectly content to
return to it before I got back on the road.

She hardly touched the toys in her carrier the whole trip and was quiet
after the initial 45 minutes.  It was actually a bit worrisome.  She
only stirred when I took the carrier into the motel I stayed in halfway
there and she quickly returned to her normal self once I was settled in
the room and she seemed glad to get out, but the next morning, when I
resumed the drive, she went back to vegging out in the carrier and
didn't stir at all when I got pulled over for doing 90 in a 75.  (Check
out my ride:  http://home.comcast.net/~pdw420/ride.jpg notice the
scratching posts on top of the car.)

Here's a picture of her in her "cage":
<http://home.comcast.net/~pdw420/kittycage.jpg> - she doesn't look too
happy, but moving was a hassle for me too.  We both survived.

BTW, the plastic "cage" she's in is her new carrier.  Her old carrier
was fabric, but smaller and can be partially seen on the left of that
picture - it was perfect for holding all her toys.

First thing is have you checked at the hotel to see if they allow
cats?  Many of them will not.

As far as the seditive, i'd refer you to your vet.   Especially where
the cat is ill.  

about a year or two back I moved from the lower mainland up north. well it
was an adventure, my two cats one (god rest that little critters soul) was
about 1 yr old and the other a little younger. Both times in the car they
were hysterical, mewing and yowling it sounded like a little siren in my
car. when I did the big moved I put them in sperate carriers and placed
towels over the top of them making sure that there were vent holes left
uncovered for them to breathe fresh air. They slept almost the entire way
and barley made a peep. I stopped for a while and wamted to see if they
would come out, but they were sound asleep and cozy in their little safe
caves. I think it was the fact that it was warm and dark and they were both
quite pleased on the trip. Anyway I hope this can help you a little.>