How long is the trip?  I know you posted the information, but I don't recall
the specifics.  If it is overnight, travel with a supply of motel
directories.  They will indicate whether small pets are permitted.  Don't
wait until the last minute to get a room because it is sometimes difficult
to find accomodations that permit pets.  Phone ahead and make reservations.

I always travel with water and extra food.  However, I don't get out the
food until we reach the motel, and none of my cats have wanted water while
they were in the car.  Still, you want to be prepared.  I also keep an open
litter box (fresh litter!!) on the floor in the back seat.  Again, none of
my cats used it until we reached a motel; but at least it is available.

Keep Kami on a harness and leash at all times if she is not in a carrier.
Don't take any chances that she might panic and jump out of the car.  This
especially includes stops at toll booths, drive-through eating, or any other
place where you have to open the window.

I never leave my cats alone in the car except for the very shortest of
restroom stops.  This means that I use drive-through for lunch and eat in
the car.

My cats have never caused any type of damage in a motel room, but I do
travel with a small hand-held vacuum cleaner and vacuum up any signs of cat
litter outside the box.  I also leave an extra tip for the maid.

MaryL
(take out the litter to reply)

In addition to my last post:  Get a health certificate and keep it with you
if you are going to cross state lines.  I have never had anyone ask for
mine, but some states do require the certificate and proof of rabies
vaccination -- "better safe than sorry."

MaryL

I can see disaster brewing. You're going to give a cat subcutaneous
fluids then close it in a travel carrier for hours? Yikes!

When I moved across country I offered water and a litterbox every 3-4
hours, driving 10 hours a day. They refused both, and Hektor peed
himself in the carrier every day, having to sit miserably in it. Tips
One and Two: Drive eight hours or less, and line the carriers with
disposable diapers.

My boys were already accustomed to two feedings per day, mostly of
canned food. They continued with this habit during the trip. I'm sure
this helped their hydration. Tip Three: bring paper plates for the cat
to eat off of and a fork to dish the food out with.

My AC went out during a heat wave through the middle of the country.
Before transferring the boys to the airconditioned moving van my husband
was driving, I spritzed them frequently with water. This kept their
temperatures down and was probably another good source of moisture as
they groomed it off themselves. Although if you're moving soon you
probably won't hit any heat waves, that's Tip Four: keep a spray bottle
of potable water on hand.

Enjoy your trip.
-Alison in OH