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Cat Forum / Health and Behavior / July 2005

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Liver disease...this is killing me...(long)

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NateB323 - 13 Jul 2005 20:39 GMT
madsongstress Wrote:
> Hey there, here's my experience FYI:
> Last year around memorial day, my cat Fritz wouldn't eat either and wa
> vomiting foam. Rushed him to the vet, the result, hepatitis.
> He was put on amoxicillan, then a few weeks later prednisolone an
> metronidazole.
> He only got marginally better, and had an ultrasound, needle biopsy
> few months later. I was scared I would lose him because he was 18 year
> old at the time.
> He got through the surgery just fine, albeit with funny looking bal
> droopy stomach, and the results showed no enlargement of the liver an
> generally inconclusive. Chronic Mild Inflammation. We are working unde
> the assumption that he has cholagial hepatitis. I did get his teet
> cleaned up in October in case all the mouth bactieria was contributing
> I was scared again he would just die when knocked out but again he mad
> it through just fine.
> He was vomiting liquids every morning like clockwork around 5:30 am.
> was thinking for a long time this was old age, or the result of live
> inflammation, but turns out it was stomach acid. This has since bee
> almost completely eliminated by slippery elm powder and small sliver
> of Pepcid AC (never Pepcid complete, has harmful stuff)
> Well, to make a long story short, it has to be managed til he dies. Al
> the vets have not been optimistic that he can go into remission. Not a
> his age.
> He still gets Prednisolone, 5 mg every other day to keep th
> inflammation down, and the Metronidazole and Amoxidrops keep bacteri
> at bay. When I tried to wean him off those meds the result was a
> opportunistic infection that messed up his voice and ruined hi
> appetite until a week of clavamox and reintroduction of the meds fixe
> him up, but it took weeks. This was in March of this year.
> He is now anemic from lowered kidney function (i've been giving hi
> sub-q's at home for a few months now) and chronic inflammation, so soo
> we will be trying Epogen to see if that helps him. His Hematocrit ha
> dropped to 20, should be 29-38 or so. He's gotten a bit wobbly an
> lowered energy.
> His kidney values continue to be high (around the 500's) but his BU
> Creat have almost normalized since hydrating him.
> The vet says his condition is part of a common triad syndrome tha
> usually goes along with Irriitable Bowel Syndrome (which he did hav
> around age 9 but which we thought was gone, good diet made symptom
> disappear)
> The vet says the immune system MUST be suppressed with the Pred to kee
> his liver from being destroyed. She thinks the inflammation is th
> result of a faulty immune system.
> He has lost weight, used to be a 9 or 10 lb cat, but in the last fe
> years got down to 7.3 at time of diagnosis, then over the last year i
> down to 5lbs.
> It's very heartbreaking, I've been depressed, sleepless and found
> counselor.
> The weight loss is the hardest, he is so bony. They think at this poin
> he only has a few more months, but is a trooper. He's not tha
> jaundiced, only slightly pale yellow, not in pain, and not nauseaus.
>
> Things I have learned in managing his disease:
>
> Higher doses of Pred have helped his appetite emmensely
>
> Actigall or Urisidiol very good for keeping the bile flowing & bil
> ducts cleaned out. Protects against bacteria all jammed up in there
> Ask your vet about that one.
>
> Denosyl can make him nauseaus & inappetance, so I use sparingly
> Denosyl MUST be given with a little syringed water to wash it down o
> it sticks in the throat & irritates it.
>
> I give the metronidazole at night since it's bitter & can mak
> nauseaus, so why not let him sleep through that.
>
> Combining all pills in a gelcap is VERY helpful, we've got the routin
> down to 2 gelcaps a day, morning & night. I give with syringed foo
> since that washes down the pill.
>
> A really good small shooter syringe works best for feeding. Not th
> dropper kinds. The nozzle can be snipped off to suck the food u
> better. I have a 3cc shooter, it takes about 10-15 syringes to feed
> decent size meal. Syringes must be thrown out often to prevent
> bacteria. I go slow while I'm doing other things, a syringe every few
> minutes snuck in the side of his mouth. He doesn't even dribble it
> anymore, and doesn't hide or dread being fed. Patience and getting into
> a routine are a must. I can even feed him on my bed or futon & don't
> even have to trap him in the bathroom anymore.
>
> One pinch slippery elm powder added to each meal keeps digestion moving
> along (works on constipation as well as diahrrea)
> A constipated cat is NOT happy.
>
> I must add Lixotinic & liquid B vit to each meal or anemia worsens. I
> hear Pettinic also good.
>
> Blood pressure in old cats MUST be monitored. His was 280 in Feb so
> he's on Norvasc & Benezapril. Had we not caught that, he could have
> gone BLIND from retinal detachment. I knew nothing about this til it
> came up.
> Lowered kidney function can cause high BP.
> Fritz was howling in the mornings & very hypertensive til BP under
> control, now he doesn't howl & is much calmer.
>
> Websites like FelineCRF have been very helpful in helping me figure out
> how to handle all the symptoms & manage the disease. Very helpful people
> on the forums there.
>
> It has been very hard & depressing, I've had him 19 years 7 months so
> every week is a gift. He is very thin & tired but still gets lots of
> enjoyment out of life, loves his yogurt treat & the occasional bite of
> salmon. He eats some on his own, his appetite has been better since
> upping the pred. He loves Pet Guard food, I always give wet since dry
> makes him barf. Overall his life quality is very good but he is on the
> decline & it's so hard. I expect to have him a few more months, maybe
> even til the end of the year, but I do cherish every moment. It has
> helped me to accept the condition instead of trying to cure him, for a
> long time I was doing so much research & trying everything on him, but
> at this point, it's just being managed & he is comfortable. But
> everything I've researched indicates keeping on the Pred, Metron, and
> Amox VERY important.
>
> My heart goes out to you, maybe your cat is young enough for a
> remission. With careful diet maybe that's possible. Please continue to
> research & try different diets & supplements, and by all means watch
> out for Anemia & Blood pressure! Also diabetes if his Pancreas is
> affected.
>
> Purrs, hugs & best of luck:
> madsongstress

Thank you very much for this response and all the others as well.  I am
having a hard time with this as I described before.  Madsongstress, TB
has been on the clavamox, metro, Denosyl for around 6 months now.  In
the beginning I had him on the Actigal, but my vet told me to stop it
incase he had a bile duct obstruction.  I heard that stuff works
wonders though, but my vet insists they need to be sure there isn't a
blockage before using it.  I also have tried Prednisone on multiple
occasions in multiple doeses.  It worked in the beginning, but TB does
not tolerate it well now.  I recently tried to restart him on 2.5mg a
day and he regained a little appetite for a week, but then turned how
is now.  The Pred seems to give him a gallop heartbeat and diarreah.
So, I really don't think Pred is going to do him any good at this
point.  I use the Pepcid AC too, and that really helps with vomiting.

This last visit to the vet, (after he crashed on the Pred) the blood
tests showed his consistantly high liver enzymes (ALT usually in the
800-900 range) and Bilirubin of 14.  They also said he has a borderline
anemia and for the first time in his life his kidney values were
"slightly elevated" his Creatinine was 3.  Since I have had him home
from the vet the last 4 days, he has been very lethargic, no appetite,
just walks around and then sits or lays.  I have been getting about 2
cans of Hill's Senior in him throughout the day and night via syringe.
I didn't think about changing out syringes often, but it does make
sense...I do wash it in the washing machine though.  

I'm worried that I need to get him back in the vet on IV fluids to get
him going again.  He hates the vet so much and screams and carrys on
when he is there, I hate to take him.  Plus, I have spent so much $ it
is unbelieveable...I hear what you are saying about the surgery, I just
need to be sure TB would recover from it and not die from the process
and recovery.  These are the hardest days I have had in a long long
time.  I appreciate your support and I will keep you updated
Meghan Noecker - 14 Jul 2005 01:23 GMT
>I'm worried that I need to get him back in the vet on IV fluids to get
>him going again.  He hates the vet so much and screams and carrys on
[quoted text clipped - 3 lines]
>and recovery.  These are the hardest days I have had in a long long
>time.  I appreciate your support and I will keep you updated.

Ask about doing fluids at home. I paid $25 for a one liter bag of
fluids. The vet told me to give him 100-150mL each day. And we would
re-evaluate him at that time. Once we got to a good level, then we
could cut back to 100mL as needed.

She did a demo with me on Maynard. It took about 5 minutes. She
answered my questions, showed me how to set it up, and it was really
easy. Basically, you just hand the bag up for gravity to work. Pull up
an area of loose skin, and put the needle in. Keep him still with lots
of petting til the fluid level gets to where you want it. Then remove
the needle, let go of cat, and replace the needle with a clean one for
tomorrow.

It was quick and easy. Didn't bother Maynard at all since it was just
5 minutes on a lap taking in extra attention. No car trip or vet.

One demonstration, and you are good to go.

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Equine and Pet Photography
http://www.zoocrewphoto.com

 
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