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Granuloma

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Linda E - 19 Sep 2003 01:08 GMT
What actually is a granuloma?
Elaine Rene - 19 Sep 2003 02:31 GMT
I was asking myself the same when I saw your
heading .
Says in the dic. a diseased growth characterized by granulation.

> What actually is a granuloma?
PawsForThought - 19 Sep 2003 03:04 GMT
>From: "Elaine Rene" chakashiva@yahoo.ca

>I was asking myself the same when I saw your
> heading .
>Says in the dic. a diseased growth characterized by granulation.
>
>> What actually is a granuloma?

A eosinophilic granuloma is also known as rodent ulcer.  Here is a
description:  

http://www.marvistavet.com/html/body_eosinophilic_granuloma.html

http://www.appspring.com/ACVC/rodentul.htm

Lauren
________
See my cats:  http://community.webshots.com/album/56955940rWhxAe
Raw Diet Info: http://www.holisticat.com/drjletter.html
http://www.geocities.com/rawfeeders/ForCatsOnly.html
Declawing Info: http://www.wholecat.com/articles/claws.htm
Linda E - 19 Sep 2003 11:37 GMT
Thanks!

> >From: "Elaine Rene" chakashiva@yahoo.ca
>
[quoted text clipped - 17 lines]
> http://www.geocities.com/rawfeeders/ForCatsOnly.html
> Declawing Info: http://www.wholecat.com/articles/claws.htm
-L. - 19 Sep 2003 09:10 GMT
> What actually is a granuloma?

There are a number of conditions that can be diagnosed as a
"granuloma" - do you mean eosinophilic granuloma complex?

-L.
Linda E - 19 Sep 2003 11:40 GMT
> > What actually is a granuloma?
>
> There are a number of conditions that can be diagnosed as a
> "granuloma" - do you mean eosinophilic granuloma complex?
>
> -L.

My cat has developed a lump at vaccine site...most likely VAS... getting a
biopsy on Wednesday.  After my vet consulted with Cornell, they brought up
the *slim* possibility of it being a cryptococcal granuloma, as she was
diagnosed with cryptococcosis 3 1/2 years ago and had a stubborn titer.....
didn't think to question vet further about the granuloma since we were
talking about the biopsy and treatment options if malignant.

Linda
Phil P. - 19 Sep 2003 19:40 GMT
> My cat has developed a lump at vaccine site...most likely VAS... getting a
> biopsy on Wednesday.  After my vet consulted with Cornell, they brought up
> the *slim* possibility of it being a cryptococcal granuloma, as she was
> diagnosed with cryptococcosis 3 1/2 years ago and had a stubborn titer.....

Could be..  the skin and/or subcutaneous tissues are involved in about half
of crypto cats.  Granuloma formation is caused by the cat's cell-mediated
immune response to crypto.--- but I don't think the lump is related to
crypto - not with such a low titer and after all this time.

Does the lump feel soft or hard?  Does it feel like its just under the skin
and moves with the skin?  IOW, if you tent the skin (like a in skin pinch
test for dehydration), does the lump move with the skin or is it stationary
and feel like its attached to or growing from the muscle?

If it moves with the skin, it could very well be an interdermal cyst - (e.g,
sebaceous).  Eosinophilic granulomas are usually *on* the skin, not under
the skin.

> didn't think to question vet further about the granuloma since we were
> talking about the biopsy and treatment options if malignant.

Try to relax a bit and wait until you get the biopsy results.  I could be
just a cyst.

Phil.
Linda E - 19 Sep 2003 21:29 GMT
> > My cat has developed a lump at vaccine site...most likely VAS... getting a
> > biopsy on Wednesday.  After my vet consulted with Cornell, they brought up
[quoted text clipped - 23 lines]
>
> Phil.

Hi, Phil,

The lump (approx 1cm in size) feels hard and is stationary (or attached).
The vet said she thinks it is under (or in?)  a layer of muscle.  We are
rethinking having the biopsy done at our vet's and just going up to Cornell
for it.  Will talk to vet on Monday about this...

Linda
Phil P. - 20 Sep 2003 14:27 GMT
> > Does the lump feel soft or hard?  Does it feel like its just under the
> skin
[quoted text clipped - 22 lines]
> rethinking having the biopsy done at our vet's and just going up to Cornell
> for it.

Hi Linda,

Based on your description, size and location of the lump,  I'd avoid
manipulating the mass as much as possible.   I'd have some very serious
reservations about manipulating or opening a possibly cancerous mass and
leaving it in the cat -- even for a second.

I'd image the margins of the mass with ultrasounds -- in a surgical
setting -- and opt for an *excisional biopsy*  instead of an incisional or
needle biopsy.  An excisional biopsy removes the entire mass -- which can be
sent to a lab for a definitive histopathologic examination.

If you opt for an incisional biopsy and the tumor turns out to be cancerous,
you'll have to subject Betsy to a second surgery.   The first surgery is the
most important and has best chance of producing a complete cure.   The
complete surgical removal of a localized cancerous mass cures more cats than
all other treatments combined
To my mind, the small size and relatively shallow location of the mass makes
an excisional biopsy the wisest choice.

Please keep me updated.

Good luck.

Phil.
Linda E - 22 Sep 2003 01:49 GMT
> > > Does the lump feel soft or hard?  Does it feel like its just under the
> > skin
[quoted text clipped - 52 lines]
>
> Phil.

Phil,

We have been rethinking this all weekend....  We were thinking that maybe
they can do the biopsy *and* ultrasound/CT scan at the same time, ( I assume
the cat will need to be drugged or put to sleep for the ultrasound?) but
didn't think about having the whole thing excised at that time.  I will be
calling my vet in the a.m. and getting the name of the oncologist that she
talked with so I can discuss it with them.  Thanks again.
Linda
Phil P. - 23 Sep 2003 10:15 GMT
> > > > Does the lump feel soft or hard?  Does it feel like its just under the
> > > skin
[quoted text clipped - 65 lines]
> they can do the biopsy *and* ultrasound/CT scan at the same time, ( I assume
> the cat will need to be drugged or put to sleep for the ultrasound?)

Linda,

Ultrasounds can be performed on awake cats but some cats might need a mild
sedative.  Cats *definitely* need to be heavily sedated or anesthetized for
CT.  If you opt for an ultrasound-guided excisional biopsy, of course she'll
need to anesthetized.

In this case, I think an ultrasound-guided excisional biopsy would be a
better choice than CT.  Also, if you're having the surgery done at Cornell,
their ultrasound machines are fully equipped with Colorflow Doppler and even
power Doppler which will show exactly where the major vascular structures
are in relation to the mass so they can be avoided during surgery.  This
greatly reduces bleeding and minimizes the risks of hemorrhage and also
shortens operative and anesthetic time.

.

but
> didn't think about having the whole thing excised at that time.

I would. The biopsy slice wouldn't be much smaller than the entire lump!

I will be
> calling my vet in the a.m. and getting the name of the oncologist that she
> talked with so I can discuss it with them.  Thanks again.
> Linda

Keep me posted.

Good luck.

Phil.
Linda E - 22 Sep 2003 11:53 GMT
> > > Does the lump feel soft or hard?  Does it feel like its just under the
> > skin
[quoted text clipped - 52 lines]
>
> Phil.

Question, Phil:

If we do an ultrasound pre-excision and the margins are not "even" (or
whatever the term meaning "good" is), would they likely choose to do
radiation before surgery, without doing a biopsy first to confirm that it
*is* cancer?

Linda
Phil P. - 23 Sep 2003 10:17 GMT
> > > > Does the lump feel soft or hard?  Does it feel like its just under the
> > > skin
[quoted text clipped - 64 lines]
> If we do an ultrasound pre-excision and the margins are not "even" (or
> whatever the term meaning "good" is),

That's the beauty of real time ultrasounds - they show the limits of the
tumor growth even if the tumor isn't well-marginated.  For example, real
time ultrasounds can determine if a mass is growing from within an organ,
adhered to the organ, or merely touching the organ.

would they likely choose to do
> radiation before surgery, without doing a biopsy first to confirm that it
> *is* cancer?

I don't think your vet would choose radiation before surgery as a
prophylactic.

Phil
Linda E - 23 Sep 2003 11:37 GMT
> > > > > Does the lump feel soft or hard?  Does it feel like its just under
> the
[quoted text clipped - 84 lines]
>
> Phil

Phil,

Spoke with the vet again yesterday and after (her) consulting again with
Cornell, they are *still* suggesting doing the biopsy first....... we are
going to go ahead with the biopsy (by my vet) tomorrow and will follow up
with surgery at Cornell.

I'm so confused....... Will keep you posted.  Linda
William Hamblen - 19 Sep 2003 10:44 GMT
> What actually is a granuloma?

Granulomas are non-cancerous tumors containing granulation tissue.
Cats sometimes get eosinphilic granulomas.  Eosinphils are cells that
are associated with inflammation or allergic reactions.  They treat
eosinphilic granulomas in cats with steroids such as prednisone.  I had
a cat that had a spell of rodent ulcers or eosinphilic granulomas on
his lip.  He was treated with oral prednisone and recovered completely.
He never was troubled with them again.  The vet said they were called
rodent ulcers because at one time they were believed to be caused by
eating mice.

Signature

When the fog came in on little cat feet last night, it left these little
muddy paw prints on the hood of my car.

Alison - 19 Sep 2003 11:22 GMT
Hi William ,
I'm not sure that rodent ulcer and eosinphilic granuloma aren't
exactly the same thing , AFAIK a rodent ulcer occurs on the top lip
and the second is when the bottom lips (trout pout<G>) swells although
the cause is the same.
Kim gets a reaction to flea treatment but if I dont treat her , she
gets a reaction to fleas . Catch 22!
Alison

> > Granulomas are non-cancerous tumors containing granulation tissue.
> Cats sometimes get eosinphilic granulomas.  Eosinphils are cells that
[quoted text clipped - 9 lines]
> When the fog came in on little cat feet last night, it left these little
> muddy paw prints on the hood of my car.
Linda E - 19 Sep 2003 11:41 GMT
Thanks for the info!
Linda

> > What actually is a granuloma?
>
[quoted text clipped - 7 lines]
> rodent ulcers because at one time they were believed to be caused by
> eating mice.
 
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