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TK's heart murmur. Bad to worse.

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Nomen Nescio - 20 May 2005 07:50 GMT
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Well, I have a diagnosis on TK's condition. I've known
for a couple of days but couldn't bring myself to post
an update.
At an age of about 2 y.o., TK has moderate Hypertrophic
Cardiomyopathy.  I watched the echocardiogram being
done and it was obvious even to my untrained eye.
Prognosis: He could die tonight or he might live up to
another 6 years.
Treatment: He's getting an aspirin (81 mg) twice a week.
Although the vet admitted that if you had 100 cats that
you knew would die of a blood clot within a year and gave
them all aspirin, 95 would still die.
And he's getting 30 mg of Diltiazem ER daily, mostly to lower
his heart rate but there are other potentially positive
effects.
And he should lose 3 lbs to bring his weight down to about
11 lbs.
Cause: This is the tough part. One of the first questions
that I asked the vet was "Could I have done something to
cause this...chemical, environmental.... ?" He shook his head
and said "No" but then in further discussion 2 points jumped
out at me.
1) He pointed at the chart of cat weight conditions (the one
that every vets office has on the wall) and indicating the
picture of the slightly underweight cat said that "You rarely
see heart problems in a cat like that".
2) He also said that "You rarely see heart disease in an
outdoor cat"
Well, TK isn't obese, but he is overweight. He was about
10 3/4 lbs last year when we took him in. And he was an
outdoor cat.

So here's my take on the situation:
Last year I adopted a wild cat with the intent of treating
the bite wound on his butt, and giving him a good home
where he would be well loved and well fed.
And what did I really do? Take a cat that was perfectly
happy living outdoors and visiting us for food and a little
play. Then I locked him in the house, cut his balls off,
made him fat and lazy, and gave him heart disease.
All the while thinking how much I LOVE the little guy and
how I want the best for him.

I feel like such an a.shole, right now.
-L. - 20 May 2005 08:26 GMT
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>
>  Well, I have a diagnosis on TK's condition. I've known
> for a couple of days but couldn't bring myself to post
> an update.

<snip>

Don't kick yourself.  HCM is commonly genetic as well.  Many, many cats
live YEARS with it.  You did a good thing, taking him off the streets.

-L.
Phil P. - 20 May 2005 09:30 GMT
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>
[quoted text clipped - 10 lines]
> you knew would die of a blood clot within a year and gave
> them all aspirin, 95 would still die.

Speak to a cardiologist about Nattokinase- its a new fibrinolytic enzyme
that comes from the vegetable cheese natto.  It not only dissolves clots,
but might even prevent them.

> And he's getting 30 mg of Diltiazem ER daily, mostly to lower
> his heart rate but there are other potentially positive
> effects.

Did your vet tell you long-term use of Diltiazem has *reversed* myocardial
hypertrophy in many cats with HCM?

Diltiazem also has antiplatelet activity in cats.  Here's a direct quote
from Mark Kittleson:

"It appears that the incidence of systemic arterial thromboembolism  in cats
with hypertrophic cardiomyopathy has decreased since the advent of using
diltiazem."

> And he should lose 3 lbs to bring his weight down to about
> 11 lbs.
[quoted text clipped - 3 lines]
> and said "No" but then in further discussion 2 points jumped
> out at me.

> 1) He pointed at the chart of cat weight conditions (the one
> that every vets office has on the wall) and indicating the
> picture of the slightly underweight cat said that "You rarely
> see heart problems in a cat like that".

and

> 2) He also said that "You rarely see heart disease in an
> outdoor cat"

Your vet must know something Mark Kittleson, John Bonagura, and Philip Fox
don't know- and they're feline cardiologists and the three leading
authorities in feline hypertrophic cardiomyopathy. HCM is a *genetic*- not
an acquired disease- although hyperthyroidism causes myocardial hypertrophy
that might be similar to HCM.

http://maxshouse.com/hypertrophic_cardiomyopathy.htm

> Well, TK isn't obese, but he is overweight. He was about
> 10 3/4 lbs last year when we took him in. And he was an
[quoted text clipped - 12 lines]
>
> I feel like such an a.shole, right now.

Your vet is the a.shole, not you, for laying a guilt trip on you.  You had
*absolutely* nothing to do with TK's HCM- do you understand that?
*NOTHING*.  TK would probably be dead by now if not for you- and he probably
would have fathered many kittens who would have developed HCM later in life.
You not only saved TK's life, you did a great thing for the feline species
and all of Catdom!

Dump your vet. Go to http://www.acvim.org/Kittleson/search.htm and do a
search for an internal medicine Diplomate/Cardiologist in your area--
American College of Veterinary Internal Medicine Diplomates are about the
best there is.

If you can't find an ACVIM specialist in your area, my second choice would
be an ABVP Diplomate/Feline Specialist (American Board of Veterinary
Practitioners).  Go to http://www.abvp.com/diplosearch1.htm
http://www.abvp.com/

With the proper treatment, cats with HCM can live near-normal lifespans.

Lose the vet and guilt and keep the faith!

Best of luck,

Phil
Nomen Nescio - 20 May 2005 19:09 GMT
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Thanks, Phil. I appreciate the slap in the face to
bring me back to reality.
I've got to get through the shock, denial, panic, and
guilt phases and move through acceptance, and action.
In all fairness to the vet, he went out of his way to
stress the fact that genetics are the major factor. But in
discussing things, I latched on to two sentences that
pointed some of the responsibility in my direction. He
was just covering all the angles that he's seen as
related to HCM.....at my request. He never really said
anything like "You did this to your cat".
I had decided that the best thing thing to do, since the
follow-up vet visit showed that the murmur was still
there and seemed to have moved from from a 2-3 to
a solid 3, was to bring TK up to Tufts U. and have a
specialist in feline cardiology do the echo. He was
very good. Asked the right questions in the pre-exam
interview, explained what he was seeing as he did
the ultrasound quite clearly, and took the time to
detail his findings and thoughts in the post exam
consultation. So I really have no complaints with him.
After I got home, I was searching for more information
to try to get a better understanding of TK's condition
and was surprised to see the cardiologist's name
either referenced in, or as a co-author of, many
papers on feline heart disorders. You may know
a lot more about the guy than I do. His name is
Dr. John E. Rush.

From: "Phil P." <phil@maxshouse.com>

>Speak to a cardiologist about Nattokinase- its a new fibrinolytic enzyme
>that comes from the vegetable cheese natto.  It not only dissolves clots,
>but might even prevent them.

No, I don't think he mentioned it. As a clot preventative,
we discussed aspirin (recommended), Coumadin
(risky, as Dr. Rush put it "We have a name for that around
here.....rat poison"), and Heperin (2 injections a day, not
indicated at this time).

>Did your vet tell you long-term use of Diltiazem has *reversed* myocardial
>hypertrophy in many cats with HCM?

Yes.

>With the proper treatment, cats with HCM can live near-normal lifespans.

I'm hopeful. And since we were lucky enough to catch the
problem before he developed outward symptoms, the
prognosis is certainly better. I'm just glad that instead of
just bringing him to the vet's and getting his booster shot,
we opted to get him a full checkup even though the annual
was not due until August.

>Lose the vet and guilt and keep the faith!

I'll work on the guilt, try to keep the faith, but for now,
I'd tend to keep the cardiologist.
My wife and I just love this little guy so much that the
thought that we might have hurt him in even the slightest
way is just sickening.

>Best of luck,
>
>Phil

Thanks. And as always, your thoughts and observations
are greatly appreciated.
Phil P. - 20 May 2005 21:19 GMT
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>
>  Thanks, Phil. I appreciate the slap in the face to
> bring me back to reality.

Sorry,  I didn't mean to be harsh- its just that I think I know enough about
you to *know* how much you love your cat and how well you care for him.  I
was pissed at your vet because I got the impression he somehow made you feel
TK's HCM was your fault- which is absolutely impossible.

>  I've got to get through the shock, denial, panic, and
> guilt phases and move through acceptance, and action.
[quoted text clipped - 5 lines]
> related to HCM.....at my request. He never really said
> anything like "You did this to your cat".

Now you tell me! ;-) .  Everything you mentioned applies to almost
everyone's cat in this newsgroup!  If there's was any truth to it, we'd have
an HCM epidemic.

>  I had decided that the best thing thing to do, since the
> follow-up vet visit showed that the murmur was still
[quoted text clipped - 6 lines]
> detail his findings and thoughts in the post exam
> consultation.

Did he give you the measurements of TK's heart? If you have a print out,
look at the measurements (mm) next to "IVS" (interventricular septum) and
"LVPW" (left ventricular posterior wall). These measurements tell you the
degree of hypertrophy. Cats aren't considered HCM unless the IVS or LVPW or
both are at least 6 mm.  Let me know what the measurements are.

So I really have no complaints with him.
> After I got home, I was searching for more information
> to try to get a better understanding of TK's condition
[quoted text clipped - 3 lines]
> a lot more about the guy than I do. His name is
> Dr. John E. Rush.

As a matter of fact, I do!  He's an ACVIM Diplomate- board certified
cardiologist. TK is in good hands.

> From: "Phil P." <phil@maxshouse.com>
>
[quoted text clipped - 7 lines]
> here.....rat poison"), and Heperin (2 injections a day, not
> indicated at this time).

Coumadin (warfarin) is very tricky stuff when used in cats.  You must use
*both* warfarin *and* heparin in cats for the first few days because
warfarin also has *pro*coagulant effects that occur *before* the
anticoagulant effects start.  Also, the anticoagulant properties of warfarin
seriously increases the risk of spontaneous hemorrhaging- especially in cats
because they love to run, jump and climb. Some cats must be caged or
confined to reduce the risks of slight injuries that can cause hemorrhaging.

A thrombus usually forms in the left atrium *if* the atrium becomes
enlarged.  When the LA becomes enlarged, blood flow slows down (like a river
slows down when passes through wider areas) and blood factors start to clump
together and forms a thrombus.  The fact Dr. Rush feels anticoagulant
therapy isn't necessary is a pretty good indication that the LA isn't
enlarged significantly! ;-)))

Diltiazem also has antiplatelet activity in cats and improves LA
hemodynamics (speeds up blood flow).  So, the combination of the
antiplatelet properties of diltiazem and the antiplatelet activity of
aspirin should drastically reduce the risk of  thromboembolism.

> >Did your vet tell you long-term use of Diltiazem has *reversed* myocardial
> >hypertrophy in many cats with HCM?
[quoted text clipped - 6 lines]
> problem before he developed outward symptoms, the
> prognosis is certainly better.

Oh, hell yeah!!  You caught it early enough for treatment to really work!
The diltiazem has a better chance of reversing myocardial hyperthrophy if
the walls aren't very thick-- which in turn reduces the risk of LA
enlargement and thromboembolism.

I'm just glad that instead of
> just bringing him to the vet's and getting his booster shot,
> we opted to get him a full checkup even though the annual
> was not due until August.

I'm glad you did, too!

> >Lose the vet and guilt and keep the faith!
>
> I'll work on the guilt, try to keep the faith, but for now,

Good man!

> I'd tend to keep the cardiologist.

Now that you clarified the situation and I now know who your cardiologist
is- I wholeheartedly agree.

> My wife and I just love this little guy so much that the
> thought that we might have hurt him in even the slightest
> way is just sickening.

How do you think he'd feel if he knew you were blaming yourself for
something you had absolutely no control over? He'd probably hit you with a
left paw! ;-)

> Thanks. And as always, your thoughts and observations
> are greatly appreciated.

Keep the faith- I really mean it.

Best of luck,

Phil.
Nomen Nescio - 22 May 2005 08:09 GMT
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From: "Phil P." <phil@maxshouse.com>

>Sorry,  I didn't mean to be harsh

No apology needed. I've always appreciated your
"No BS" approach.

> I
>was pissed at your vet because I got the impression he somehow made you feel
>TK's HCM was your fault- which is absolutely impossible.

Well. in a way, he did. But not by any direct statement. To clarify
things, it's always seemed to me that people in the medical
profession, and especially vets, tend to tone down their thoughts
in the area of blame. So just because someone does not say
"it's YOUR fault", it does not mean that it's NOT your fault or even
that they are not thinking that "it's your fault". So sometimes one
has to read between the lines to get a true picture of the situation.
Unfortunately, that leaves a lot of room for misinterpretation. Which,
it seems that I did. After all, you can't pick up a newspaper without
reading how weight and exercise relate to heart disease in humans.
So I tended to extrapolate, but without the knowledge base to
differentiate between the various types of heart disease.
I just hope like hell that there really is nothing that I did to hurt TK.

> Everything you mentioned applies to almost
>everyone's cat in this newsgroup!  If there's was any truth to it, we'd have
>an HCM epidemic.

Damn good point!

>Did he give you the measurements of TK's heart?

No. Our regular vet got the full report on Thursday. We have an
appointment with her next Thurs. to discuss the report, a weight loss
plan, and get another blood workup. Everything looked fine in
the blood test last week except his white count which was a little
below normal (3300 with a normal range from 3500 - 16k). We're
also goiing to do the ELISA tests for FeLV and FIV since he has
not been tested since the day we first brought him in with the
bite wound on his butt (another thing to be nervous about).

> If you have a print out,
>look at the measurements (mm) next to "IVS" (interventricular septum) and
>"LVPW" (left ventricular posterior wall). These measurements tell you the
>degree of hypertrophy. Cats aren't considered HCM unless the IVS or LVPW or
>both are at least 6 mm.  Let me know what the measurements are.

I'll get a copy of the echo report and post the "IVS" and "LVPW".

> He's an ACVIM Diplomate- board certified
>cardiologist. TK is in good hands.

Glad to hear that you think that.

>Coumadin (warfarin) is very tricky stuff when used in cats.

I could tell he didn't like using the stuff.
If we find that we need a heavy duty anticoagulant, I would lean
toward that heparin if it's an option. Even if it is 2 injections a day
and $250 a month. If you met TK, you'd know that the 2 injections
a day would be a big problem with this cat.

>A thrombus usually forms in the left atrium *if* the atrium becomes
>enlarged.  When the LA becomes enlarged, blood flow slows down (like a river
>slows down when passes through wider areas) and blood factors start to clump
>together and forms a thrombus.

The Doppler showed a bit of turbulence. It looked like a lot, to me,
but I have nothing to base "a lot" on.

>Diltiazem also has antiplatelet activity in cats and improves LA
>hemodynamics (speeds up blood flow).  So, the combination of the
>antiplatelet properties of diltiazem and the antiplatelet activity of
>aspirin should drastically reduce the risk of  thromboembolism.

Hopefully, that's enough. For now at least.

>> My wife and I just love this little guy so much that the
>> thought that we might have hurt him in even the slightest
>> way is just sickening.

>How do you think he'd feel if he knew you were blaming yourself for
>something you had absolutely no control over? He'd probably hit you with a
>left paw! ;-)

He does that, anyway. :)

>Keep the faith- I really mean it.
>
>Best of luck,
>
>Phil.

Thanks again.
Philip - 20 May 2005 10:38 GMT
snip
> So here's my take on the situation:
> Last year I adopted a wild cat with the intent of treating
[quoted text clipped - 8 lines]
>
> I feel like such an a.shole, right now.

Some wives feel like you do about their husbands ... and for the same
reasons.   ;-)
bigbadbarry - 20 May 2005 11:08 GMT
> > So here's my take on the situation:
> > play. Then I locked him in the house, cut his balls off,

What you need is a uctimmy. (That's like on Lassie, whenever things got
foggy for the little fella, Timmy's mom would sit him and explain to him
she'd say...

You see Timmy, anyone can count the seeds in an apple, but no-one can count
the trees in a seed.
Karen - 20 May 2005 12:07 GMT
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>
[quoted text clipped - 42 lines]
>
> I feel like such an a.shole, right now.

I think that is a LOAD of twaddle. There is no way any studies have been
done to support this theory. Vets only see X number of cats. I know SEVERAL
cats of people owned in the UK that have CM and believe me they go in and
out. B.S. B.S. B.S.! Think about what is NOT truly known about heart disease
in humans. There are conflicting studies all the time. I also do NOT believe
the 3 extra pounds are the culprits. He is not some 18lb. overweight cat.
Look Grant wasn't supposed to die at 8 from stomach cancer either. He never
DID have a great immune system. My point is, TK has a loving home with vet
care. Would the doctor REALLY have any idea how many strays die of CM? What
kinds of statistics and records can he give you on this? Just be there for
TK. Love him up. It sucks that you have to face this again when some people
never do, but did it ever occur to you that since you HAVE had a cat with
this before maybe it is overall some greater plan that  you recognized some
problems right away? That you will know what to look for? That TK is with
you for a reason???? Just do your best, man. You'll waste your life AND his
if  you sit around worrying about what ifs. Give that cat a hug for me.
Nomen Nescio - 20 May 2005 19:27 GMT
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>From: Karen <kchuplis@alltel.net>

>I think that is a LOAD of twaddle.

In all fairness, it may be more my "twaddle" than the vet's.

>Think about what is NOT truly known about heart disease
>in humans. There are conflicting studies all the time.

That is so irritating, too. Read one study an it proves something
IS. Read another and it proves that it ISN'T.

> It sucks that you have to face this again when some people
>never do, but did it ever occur to you that since you HAVE had a cat with
>this before maybe it is overall some greater plan that  you recognized some
>problems right away? That you will know what to look for? That TK is with
>you for a reason????

A very good point! I think you read my little story about why
we refer to TK as our "gift from God". Maybe we had it backwards.
Maybe we're supposed to be TK's "gift from God". I just hope
that there's nothing WE did to hurt him.

>Just do your best, man.

Right now, that's all we can do.

>You'll waste your life AND his
>if  you sit around worrying about what ifs.

No, I'm an engineer. I run around in a hyperactive state
trying to solve problems.....while worrying about what ifs.

>Give that cat a hug for me.

Will do. And thank you.
Charlie Wilkes - 20 May 2005 16:01 GMT
>So here's my take on the situation:
>Last year I adopted a wild cat with the intent of treating
[quoted text clipped - 8 lines]
>
>I feel like such an a.shole, right now.

At least you can be sure no one will track you down without an armload
of subpoenas and signed warrants and advanced cryptanalysis skills.
That's worth something.

But seriously, you have done nothing wrong.  Tomcats lead short,
brutal lives.  Maybe your cat will lead a short, happy life in your
house.  You apply your best judgement, act accordingly, and accept
that you cannot forecast or control the result with any degree of
precision, because the mathematics of nature don't allow it.

Charlie
Barb - 20 May 2005 16:13 GMT
It's sad that TK has such a condition.  That kind of thing has to be
genetic.  I can't believe that it has anything to do with being an indoor or
outdoor cat.  Many in this group have indoor cats and, neutered, too, and
they don't have this condition.  It's so wonderful that you are giving TK a
home and good care.

Best of luck with all this,

--
Barb
Of course I don't look busy,
I did it right the first time.
KellyH - 20 May 2005 16:25 GMT
> So here's my take on the situation:
> Last year I adopted a wild cat with the intent of treating
[quoted text clipped - 8 lines]
>
> I feel like such an a.shole, right now.

Don't feel bad at all!!  Without you, TK would have died outside.  Read Phil
P's post.  As far as I know, HCM is genetic.  Most of the cats I've known
with it dropped dead as kittens/ very young adults.  TK is lucky, and very
lucky to have you.  You are a wonderful cat daddy!  A weight gain of a few
pounds is not going to cause a cat to suddenly develop HCM.  Should he lose
some weight?  Probably, but that's not going to cure it either.  Your vet is
a dick for making you feel like it's your fault.
I may be wrong, but aren't you in Newburyport?  There's a feline-only
practice in Salem, MA.  I don't know much about them, but from what I've
heard feline-only vets are usually much more in tune with cat healthcare.

And yes, I've seen heart problems in underweight cats.  Dash did not develop
a murmur until she was severely underweight from her multitude of health
problems.

Signature

-Kelly

Nomen Nescio - 20 May 2005 19:57 GMT
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From: "KellyH" <Kelly@farringtonsNOSPAM.net>

>A weight gain of a few
>pounds is not going to cause a cat to suddenly develop HCM.

I sure hope you're right.

>Your vet is
>a dick for making you feel like it's your fault.

He never said it was my fault. I just wonder, based on some of
the things he said, if it COULD be my fault. Just the slightest
possibility that I could have hurt him is an awful thought.

>I may be wrong, but aren't you in Newburyport?

Nope, the other side of the state. Springfield.

>There's a feline-only
>practice in Salem, MA.  I don't know much about them, but from what I've
>heard feline-only vets are usually much more in tune with cat healthcare.

We took TK up to Tufts U. for his ultrasound. I wanted a cardiac specialist
to check him out. I was very pleased with the work they did there. Just not
pleased with the result.
Mary - 20 May 2005 17:13 GMT
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>
[quoted text clipped - 3 lines]
>  At an age of about 2 y.o., TK has moderate Hypertrophic
> Cardiomyopathy.

He's so young! How heartbreaking.

I watched the echocardiogram being
> done and it was obvious even to my untrained eye.
> Prognosis: He could die tonight or he might live up to
[quoted text clipped - 19 lines]
> 2) He also said that "You rarely see heart disease in an
> outdoor cat"

Sorry, but I think this is because they generally do not live
long enough to present, having been hit by cars, poisoned
by sociopaths, or eaten by coyotes.

> Well, TK isn't obese, but he is overweight. He was about
> 10 3/4 lbs last year when we took him in. And he was an
[quoted text clipped - 12 lines]
>
> I feel like such an a.shole, right now.

I know you love your cat, but I think you are dead
wrong. Many, if not most heart problems that present
in youth are a result of a congenital predispostion, in
both cats and humans.
Nomen Nescio - 20 May 2005 20:39 GMT
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From: "Mary" <marys@catlover.com>

>He's so young! How heartbreaking.

That's an understatement.
My wife and I both feel like our entire world has crumbled.
TK's become such an important part of our life.
Mary - 21 May 2005 00:05 GMT
> -----BEGIN PGP SIGNED MESSAGE-----
>
[quoted text clipped - 5 lines]
> My wife and I both feel like our entire world has crumbled.
> TK's become such an important part of our life.

Just don't blame yourself. I am glad Phil verified what
I had heard about this type of heart disease being hereditary in young cats.
It is horrible enough without
you blaming yourself. You have been nothing but wonderful for TK.
PawsForThought - 20 May 2005 23:47 GMT
> So here's my take on the situation:
> Last year I adopted a wild cat with the intent of treating
[quoted text clipped - 6 lines]
> All the while thinking how much I LOVE the little guy and
> how I want the best for him.

I'm sorry to hear about your kitty, but this is NOT your fault.  Here's
my take.  You provided a good home for a cat that most likely could
have ended up with a lot worse than a bite wound on his butt, plus he
would have contributed to pet overpopulation.  Mostly likely his
condition is probably genetic and I don't think it's anything you did.
Much as we'd like to think they do, vets don't know everything.
ElvisRocks - 21 May 2005 03:41 GMT
Oh jeez!!!!  My heart breaks for you.  My Randall was overweight.  And when
I took Randi to the
vet before I got Cali, they said he was too fat and had a very slight heart
murmur!
I just adopted two more kittens today.
You are not an a.shole!!!  I feel so bad for you.  Life really does suck.
Carol :(\

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[quoted text clipped - 52 lines]
> =ljgE
> -----END PGP SIGNATURE-----
Nomen Nescio - 22 May 2005 07:28 GMT
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>From: "ElvisRocks" <elvisrocks1@comcast.net>

>Oh jeez!!!!  My heart breaks for you.  My Randall was overweight.  And when
>I took Randi to the
[quoted text clipped - 3 lines]
>You are not an a.shole!!!  I feel so bad for you.  Life really does suck.
>Carol :(\

I'll tell you, Carol, my wife and I are both total wrecks over this.
I keep getting a picture, in my head, of the time I woke up in the
middle of the night with Fission panting next to the bed.
But we've caught this early with TK, so we're hopeful. I just feel
so bad for our "big ol' buddy". I wanted the "best" for him and
now all he gets is the "best we can do". But he's still here, he's
still looking good, still a "wildcat". So we take it one day at a
time.
Four cats, now!?!? WoW!!
When do we see the pictures? :)
 
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