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Kitten - elevated WBC

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Cheryl - 21 Dec 2004 01:08 GMT
Some of you already know what I'm going through with one of the new
kittens. She is small, has on-again/off-again problems with her
eyes gooping up and I now have three different ointments for her,
one with steroids. The one with steroids was prescribed this past
weekend when I had to rush her off to our old vets, VCA, and they
fluoresced her eyes to make sure she didn't have any ulceration
first. The reason for the vet rush wasn't her eyes, though; she
seemed to have a seizure. Our regular vet closes at 1pm on
Saturday, so it was either there, or emergency. Her seizure-like
symptoms started an hour or two before I took her to the vet with
shivering - I turned up the heat because it *was* a bit cold in
here. Then she displayed wierd behavior in the bathroom (trance-
like) and then hopped in the bathtub and lost control of her
bladder, though not like peeing - she stood with her back arched
like she was trying to deficate, but urine ran down her legs. I put
her in the carrier to take her to the vet and she vomitted. At the
vets office, she peed on me, then she peed on the vet. She's about
3-1/2 months old, very well litter trained, and has never peed in
the tub. Vet did xray to look at her bladder (she also had a bit of
bright red blood on her anus, but no blood in her urine). Vet
thought it looked like maybe she had diarrhea and gave me some
flagyl, and some metaclopromide for the nausea and the eye
ointment, and sent us home when she seemed to be out of the
"seizure" (3 hours later). We were to await blood test results.
Today the test results came in and I missed the call from the vet,
and am still waiting, but the message said her WBC counts are
elevated and now they want to run tests for FIP, FIV and
toxoplasmosis. Scarlett was one of 4 in her litter, and at 5 weeks,
2 of the 4 were tested for FIV/FLV and were negative, so the vet
didn't test all 4.  I planned to have my two tested again this week
when they go in for neutering (Scarlett's may be post-poned again
because of her health now). Other litter mate fine, though he was
going through the same eye problems but his haven't flared up in a
couple of weeks, and he is now almost 5 lbs, where she is just 3.2
lbs.

So, to summarize:
*3-1/2 month old female, unspayed
*chronic eye issues, without ulcers
*low weight gain
*lethargic and sleeps a lot these days, though has been plenty
playful up until now (but she still has her moments)
*stinky gas often
*meows when I pick her up, but I don't know if its pain or she
doesn't want to be picked up
*xrays didn't show anything abnormal, including stomach
*low grade fever (~103.6 on Saturday)
*maybe diarrhea but I haven't witnessed it, though I've tried
*I don't know the particulars about the bloodwork results because
they haven't called me back yet.

Since I didn't get a return call today from VCA I'm going to call
our regular vet in the morning and have them request the bloodwork
results and xrays and let me know what should be done next, but VCA
was talking about FIP and toxoplasmosis. I already know that FIP
can't be screened for, correct? It can only show exposure to the
coronavirus? The Xray would have showed fluid on the stomach or
lungs if it was so far gone to have these symptoms, right?

Signature

Cheryl

KellyH - 21 Dec 2004 02:21 GMT
> So, to summarize:
> *3-1/2 month old female, unspayed
[quoted text clipped - 18 lines]
> coronavirus? The Xray would have showed fluid on the stomach or
> lungs if it was so far gone to have these symptoms, right?

How scary!  As far as I know, an accurate test for FIV cannot be done on
kittens < 6 months.  At least that's what they tell me at the shelter.
Getting them tested for FeLV isn't a bad idea.  Not trying to scare you, but
we had a litter at the shelter recently that had 2 neg kittens and 3
positive.
There is no *test* for FIP, I think what they do is test for a group of
symptoms and then call it FIP.  Phil, is that correct?  Toxoplasmosis might
be what she has.  I'm surprised the first vet didn't test for it.
Keep us updated.  Purrs that it's nothing serious.

Signature

-Kelly
kelly at farringtons dot net
"Wake up, and smell the cat food" -TMBG

Cheryl - 21 Dec 2004 02:42 GMT
> Toxoplasmosis might
> be what she has.  I'm surprised the first vet didn't test for it.
> Keep us updated.  Purrs that it's nothing serious.

Thanks Kelly. The first vet wouldn't have had reason to test for
toxoplasmosis, this past weekend was the first time anything
serious happened and they were closed already. She's always had the
eye thing, but vet said in some kittens it is going to always be a
problem if its herpes.

I can say that she's interested in food, and I've gotten some
NutraCal into her last night and tonight. She won't eat it, but
mixed with turkey babyfood she will. I'm very worried about her
weight gain, and the seizure-like symptoms this weekend were very
scary. She hasn't had another of those episodes, but she started
shivering today again for a short time and I thought "here we go
again".  I don't have a thermometer to take her temp at home so I
don't know if the fever is still there. The shivering stopped
quickly thankfully.

Signature

Cheryl

Phil P. - 21 Dec 2004 04:53 GMT
> Some of you already know what I'm going through with one of the new
> kittens. She is small, has on-again/off-again problems with her
[quoted text clipped - 54 lines]
> coronavirus? The Xray would have showed fluid on the stomach or
> lungs if it was so far gone to have these symptoms, right?

Not necessarily.  Dry (noneffusive) FIP produces very little or no fluid.
If the kitten had FIP her total plasma protein and globulin would have been
elevated and possibly bilirubin, too.

While I was reading your post, the first possibility that came to my mind
was Toxo. - but her AST & ALT would have been elevated, too.  She's also a
little too young.  Most cats are around 4 and mostly males - Of course this
really doesn't mean anything, cats of any age can be affected. Also,

What did the vet say about her eyes?  Did he mention uveitis?

Cases like this can be very tricky, so you gotta be careful.  She could have
the symptoms of Toxo and even test positive for Toxo - but Toxo may not be
the cause of her symptoms.  Toxo tests are a little tricky, too.  If you opt
for the test, got for the IgM or ideally, IgM *and* IgG antigen titers (need
only one blood sample).

Phil
Cheryl - 21 Dec 2004 20:23 GMT
> Not necessarily.  Dry (noneffusive) FIP produces very little or
> no fluid. If the kitten had FIP her total plasma protein and
> globulin would have been elevated and possibly bilirubin, too.

I got a copy of the results and dropped off another copy to our
regular vet who will see her tomorrow morning. Her total protein
isn't high, 7.1 where normal range is 5.2-8.8g/dL.  Her globulin is
also in the normal range (2.3-5.3g/dL) at 3.4.  Bilirubin is at the
low end of normal at 0.1 (0.1-0.4)

> While I was reading your post, the first possibility that came
> to my mind was Toxo. - but her AST & ALT would have been
> elevated, too.  

AST 21 (10-100 U/L)
ALT 45 (10-100 U/L)
AlkPh is high though, at 143 (6-102 U/L)

She's also a little too young.  Most cats are
> around 4 and mostly males - Of course this really doesn't mean
> anything, cats of any age can be affected. Also,
>
> What did the vet say about her eyes?  Did he mention uveitis?

No one is diagnosing this, saying it is likely from herpes, but I
read that toxo can have eye symptoms, too.

> Cases like this can be very tricky, so you gotta be careful.
> She could have the symptoms of Toxo and even test positive for
> Toxo - but Toxo may not be the cause of her symptoms.  Toxo
> tests are a little tricky, too.  If you opt for the test, got
> for the IgM or ideally, IgM *and* IgG antigen titers (need only
> one blood sample).

Thanks Phil, writing that down.

The WBC is 35.1 (3.5-16.0)

Differential:
*Neutrophils 28431 81% (2500-8500)
*Bands  351 1% (0-150)
Lymphocytes 2808 8% (1200-8000)
*Monocytes 702 2% (0-600)
*Eosinophils 2808 8% (0-1000)
Basophils 0 0% (0-150)

I guess we'll get the FIV/FLV test, and toxo. Poor little thing has
had it rough.

Signature

Cheryl

Phil P. - 21 Dec 2004 22:48 GMT
> > Not necessarily.  Dry (noneffusive) FIP produces very little or
> > no fluid. If the kitten had FIP her total plasma protein and
[quoted text clipped - 40 lines]
> *Monocytes 702 2% (0-600)
> *Eosinophils 2808 8% (0-1000)

The hemogram looks a hypersensitivity reaction.  Could she have gotten into
something?  How long has she had the problem?

P

> Basophils 0 0% (0-150)
>
> I guess we'll get the FIV/FLV test, and toxo. Poor little thing has
> had it rough.
Cheryl - 22 Dec 2004 18:43 GMT
> The hemogram looks a hypersensitivity reaction.  Could she have
> gotten into something?  How long has she had the problem?

The seizure-like thing Saturday was the first time I've seen that
in her. Her eyes have had problems since they were all rescued at ~
5 weeks. Her brother had the same eye problems when I brought them
home but his hasn't recurred in nearly 2 weeks. There are 2 other
littermates, but they were adopted by other people and I have no
idea how they are doing. Her fever was down today, and her appetite
has been fine.  

As for getting in to something, I've been very careful since the
jumping-in-the-oven (not preheated!) incident at Thanksgiving so I
don't think so. The only thing I could think of was Christmas
Cactus but they're not on the toxic plant list. I've moved them
where they can't get at the dropped flowers just in case.

Vet took blood for a bio-something screen this morning that
includes fiv flv fip (fecv) and toxo (igG and igM like you
suggested). Should know parts of it tomorrow and the rest Friday.

Weird thing about her eyes is that while the redness has mostly
cleared up now (again!) she still seems very sensitive to light.
Thats the best way I can describe the way she has them squinted all
the time. She hasn't gained as much weight since I brought her home
(Nov 6th), very unlike her brother. She was 2.2 pounds at 8 weeks
(he was 3.2 lbs) and last week she was only up to 3.2 pounds (him
4.8). Today her weight was 3.8 so we're again on track). No more
signs of seizures since the first. I know it is possible for her to
have something like this when I'm not around, but I hope it hasn't.

Thank you,

Signature

Cheryl

KellyH - 23 Dec 2004 00:29 GMT
I hope little Scarlett continues to do well.  I know the waiting sucks.

Signature

-Kelly
kelly at farringtons dot net
"Wake up, and smell the cat food" -TMBG

>> The hemogram looks a hypersensitivity reaction.  Could she have
>> gotten into something?  How long has she had the problem?
[quoted text clipped - 28 lines]
>
> Thank you,
Cheryl - 23 Dec 2004 01:38 GMT
> I hope little Scarlett continues to do well.  I know the waiting
> sucks.

Thanks Kelly. This is the second time that I've had to put off her
spay surgery. Rhett is getting done tomorrow, so at least she'll be
safe if it takes a while. He already seems like he's reaching sexual
maturity, so it is none too soon for him. I think it's too young for
him to be coming to age, but the vet was skeptical that he is even
from the same litter as her. I saw his pic taken on Oct 15th, and he
still had eyes somewhat blue, so I know he was at least close to 5
weeks at that time. Maybe he's an early bloomer.

Signature

Cheryl

KellyH - 23 Dec 2004 01:54 GMT
> Thanks Kelly. This is the second time that I've had to put off her
> spay surgery. Rhett is getting done tomorrow, so at least she'll be
[quoted text clipped - 4 lines]
> still had eyes somewhat blue, so I know he was at least close to 5
> weeks at that time. Maybe he's an early bloomer.

He could be an early bloomer, like you said.  We had a 4 month old kitten at
the shelter and the vet said by looking at her ovaries, she was just about
to go into heat!

Signature

-Kelly
kelly at farringtons dot net
"Wake up, and smell the cat food" -TMBG

Cheryl - 24 Dec 2004 04:26 GMT
> The hemogram looks a hypersensitivity reaction.  Could she have
> gotten into something?  How long has she had the problem?

Forgive my second followup to your message, but it appears that it
may have been something of a reaction that caused her WBC count to
spike because all test results came back negative. Not even exposure
to the CV. She's much better today and playing again, and I'm just
getting as much food into her that she'll take. The Antirobe may have
something to do with her feeling better, for whatever that's worth.
This girl may well get spayed soon afterall. lol Well at least she's
safe since her brother was neutered today.

Signature

Cheryl

KellyH - 24 Dec 2004 13:37 GMT
> Forgive my second followup to your message, but it appears that it
> may have been something of a reaction that caused her WBC count to
[quoted text clipped - 4 lines]
> This girl may well get spayed soon afterall. lol Well at least she's
> safe since her brother was neutered today.

Yay!!!  I'm so glad your little girl is doing better :)  Looks like it
wasn't anything serious.  Keep us posted on the babies and keep the pictures
coming!!

Signature

-Kelly
kelly at farringtons dot net
"Wake up, and smell the cat food" -TMBG

Cheryl - 25 Dec 2004 04:21 GMT
> Yay!!!  I'm so glad your little girl is doing better :)  Looks
> like it wasn't anything serious.  Keep us posted on the babies
> and keep the pictures coming!!

Thanks Kelly. I can't tell you how relieved I am. And, I have a lot
more pictures, I just need to find time to put them on their Yahoo
page. :) Rhett is WAY bigger than Scarlett; you'll be amazed.

Signature

Cheryl

Phil P. - 25 Dec 2004 10:39 GMT
> > The hemogram looks a hypersensitivity reaction.  Could she have
> > gotten into something?  How long has she had the problem?
[quoted text clipped - 7 lines]
> This girl may well get spayed soon afterall. lol Well at least she's
> safe since her brother was neutered today.

I thought it might be a reaction of some sort. Elevated eosinophils
("Eosinophils 2808 8% (0-1000)") usually, but not always, indicate some kind
of a hypersensitivity/allergic reaction.

Allergies/hypersensitivities are cumulative - a few individually may not
cause a problem, but put 'em all together and the cumulative effect can
cross the immune threshold and cause a reaction.  Finding the culprits can
be a nightmare.

I'm happy she's feeling better.

Phil.
MacCandace - 22 Dec 2004 03:58 GMT
<< I guess we'll get the FIV/FLV test, and toxo. Poor little thing has
had it rough. >>

Cheryl, I'm so sorry you're having these problems.  I had no idea.  I hope
everything is okay and I can imagine how concerned you are.  Paws crossed that
it's just one of those kitten things.  Poor little girl.

Candace
(take the litter out before replying by e-mail)

See my cats:
http://photos.yahoo.com/maccandace

"One does not meet oneself until one catches the reflection from an eye other
than human."  (Loren Eisely)
Cheryl - 22 Dec 2004 18:43 GMT
> Cheryl, I'm so sorry you're having these problems.  I had no
> idea.  I hope everything is okay and I can imagine how concerned
> you are.  Paws crossed that it's just one of those kitten
> things.  Poor little girl.

Thanks Candace. Hopefully the tests run today will turn up something,
or rule out some of the infectious diseases.

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Cheryl

 
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