I drove my cat from CA to ND... and then from ND to OR on a move.

This advice is good, I also used a large metal crate in the back of my
wagon with a small litter box. The cat rode in his carrier, which was
buckled into the front seat beside me. (I always buy carriers I can
secure with a seatbelt.) I did not let him roam around the car.

I did ask my vet about meds, but he rather laughed, and said don't
bother, as my cat was a pretty mellow sort and had always been good in
the car for short trips.

Anyway, Gray had not ridden for such a long time in the car before,
and while we made stops at rest areas the first day to offer him his
*bathroom*, he did NOT make use of it. Instead, while we were in a bad
place for pulling over, he suddenly started to howl just outside of
Reno and I *knew* what he wanted.

Fortunately, we made our hotel parking lot, where I didn't bother
waiting for our room, I quickly decanted him from his carrier to his
potty cage and let him do both jobs. THEN we found a room, LOL!

By the next day though, he understood what was what, and shortly after
we hit the road, he howled, I found an exit, offered him his potty and
he used it. Then he was good for most of the day. If he was peaceful
and sleeping, I wouldn't bother him at rest stops, but if he was up or
acting agitated, he got a chance to use his box.

I fed before leaving the hotel and on arrival at the next hotel.

The only real trouble I had was that it was HOT going through Nevada
and he simply refused to drink while on the road, even at rest stops.
I had to force water into him with an eyedropper that one day, because
I could see he was getting dehydrated. Otherwise, he drank morning and
night at the hotel, which was his usual pattern.

Anyway, it was a 5 day road trip to ND and he was a trooper after the
first day! Next time we moved, he remembered the entire drill.

Yes, this is a good idea. We actually had to live in a hotel for about
a month, while we searched for a house to buy on our last move. I had
brought a piece of berber fleece that Gray liked, and we laid that
over the end of the bed so he had something familiar. I had also made
sure to bring his own cat bed and some toys.

I put him in his metal crate for when we needed to let a maid in to
vaccum/tidy. I also had his harness and leash along, so that I could
walk him once a day out back of the hotel on a quiet grassy stretch,
so he could get a little extra exercise and not be too bored. Whether
you go this route or not would depend on the cat!

It is also a good idea to have things like vaccination certificates
along with you just in case. And if this is a move, get your cat's
records from the vet... your new vet may like to have a copy.