My 6 year old female hisses at our 1 year old male but he chases her
every chance he gets. I didn't know a cat could hiss and run at the same
time!  He hisses at my mother in law every morning when she opens the
bedroom door - wish I could too  :)

After 8 years? No, I think the hissing is just auto response. Their ok.
Believe it or not, even cats who appear to not like each other apprecieate
the company.
Karen

You should consider putting the older one to sleep, hissing is a sign
of rebellion and agression. If you don't you may wake up to find the
older cat introducing the younger one to illegal drugs and how to hide
syringes in the litterbox, which is very unsanitary and may cause
serious infections.

Victor Martinez

Yes. Active noise cancellation technology.

Failing that, some cats are just mardy hissing buggers, like one o'
mine indeed. Said cat will hiss if the other cat steals his food, if
he doesn't like my shoes, if the room is at room temperature, and so
forth.

If there's no serious scrapping, I wouldn't worry.

Steve.

Nope, there's no way to solve it. Cats hiss. It's a form of
communication to them. If the cats have lived together for as long as
eight years, then their relationship is what it is. It's really not
going to change dramatically at this point.

Believe it or not, your solution may be to get another cat -- a neutered
male, probably, to play with the younger cat.  This worked well for me in a
situation identical to yours. -- L.

My cats have been together for 13 years - the female still hisses at
the male.  Normal behaviour - hissing is a warning.

-L.

I have had a similar experience with my female, she started hissing at
everything after losing her eye-sight to old age. Whenever she would
bump into a toy or a piece of furniture she would start with the
hissing. I had the veteranarian to remove her tounge to stop the
hissing, he said it was the best thing to do. She is very happy now
and doesn't get hairballs either, but I have to clean her daily.

Tina

Cody hisses whenever he gets mad at Midnight. I just let him do it,
since Midnight will back away and they'll avoid a fight.

circa 20 Apr 2004 11:31:02 -0700, in rec.pets.cats.health+behav,
Laura (lauracuthill@hotmail.com) said,

Camille is 11. Oscar will be 10 on November 1. They had the same
(stray/feral) mamacat, and Oscar has never known life without
Camille. Still, at least twice daily he picks on her and she hisses
at him. Then she'll walk up to him and head-butt him for a lick
between her ears.

Cats are contrary creatures. Sometimes you just have to live with
knowing you're not going to change 'em. :-)

Laura