Cat Forum / Health and Behavior / March 2006
chronic pancreatitis
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teri - 03 Mar 2006 02:11 GMT Does anyone have experience with chronic feline pancreatitis? Seamus was diagnosed by ultrasound Feb 1, and has been on torbutrol for the pain since then. He is no better when I have tried to wean him off the pain med. He has a great appetite, no vomiting or diarrhea (soft stools when the torb is decreased), just the signs of pain - hunching, very quiet, not running or playing (he is normally *very* active). This is his first bout with this, and it is a long time to have to see him like this. He is getting 1/2 of a torb once or twice a day before meals, then he will play. I am also concerned about keeping him on the opoid that long. When will he feel better? Teri
yngver - 03 Mar 2006 19:17 GMT > Does anyone have experience with chronic feline pancreatitis? > Seamus was diagnosed by ultrasound Feb 1, and has been on torbutrol [quoted text clipped - 7 lines] > about keeping him on the opoid that long. When will he feel better? > Teri Pancreatitis is hard to diagnose and often seems to resolve by itself no matter what you do. Our cat had the symptoms you describe (although the vet did not do ultrasound) and on a hunch the vet sent out for a pancreatic enzyme assay (called TLI). Unfortunately this kind of test takes 3-4 weeks to get results and by the time the results did come back, my cat had completely recovered. But the vet said the test did show evidence of pancreatitis. I think this test is not certain either, but the best test currently available. While our cat did show signs of pain (hunching, walking very slowly) she was also not eating. Thinking it might be some kind of infection the vet also prescribed an antibiotic and he gave us an appetite stimulant. Once she started on the antibiotic, it only took one dose of the appetite stimulant and she started eating again. After that she began to recover.
I guess my point is that it's hard to be sure that a cat has pancreatitis--the vet isn't even sure that our cat really had it despite the assay. However, if your cat has been in pain from pancreatitis for a month, I'd think I'd want the vet to see if anything more can be done. It is a painful condition and I think sometimes vets prescribe Fentanyl patches to control the pain. But it seems to me that in a month it would have started to heal and become less painful. -Yngver
Alice - 03 Mar 2006 22:10 GMT Hi Teri, keep giving him torbutrol! Chronic feline pancreatitis outlook is usually judged to be bad to fair. Opioids are really the least of your problems.
While pancreatic inflammation can be visible via ultrasound the only way to diagnose it is to do PLI/TLI blood test (the turn-around is usually 7 days - the test needs to be sent to laboratory in Texas; my cat's results came back in 5 days). TLI alone, especially in cats, is not always indicative. PLI/TLI test IS conclusive. It is important to do this test because lymphoma has exactly the same symptoms and also presents as an inflammation on abdominal ultrasound (you'll need biopsy or at least laparoscopy to fully diagnose lymphoma).
It's wrong to think that chronic pancreatitis resolves itself - it does not. It's a chronic disease marked by returns of acute periods. Once it presents itself, it always comes back. There is, at present, NO treatment for it.
Sometimes, but not always, pancreatitis is caused by infection in the GI track. The theory goes that bacteria backs down to pancreatic ducts and causes inflammation. For that possibility vets usually prescribe a short course of antibiotics. The antibiotics do nothing for pancreatitis. Be resistant to prolonged use of antibiotics if there is no improvement after first two weeks. My cat's pancreatitis wasn't caused by infection and I wasted a month giving him antibiotics.
Another thing, if he's not getting better maybe you should consider steroids? My cat, for as long as he was only on painkiller and some supportive medicine, did NOT improve. In fact, he got worse and I ended up regretting I didn't give him steroids sooner (this disease took a lot out of him, he's aged a lot). Budesonide (rather 'mild' steroid) made him better in just few days. (Btw, it's important to exclude lymphoma because steroids without chemo are not a good cancer treatment.)
Other things you might want to consider before adding steroid therapy: - Subcutaneous fluids (really easy to learn and very helpful) - Vit. B12 injections (can be added via IV port during sub-q fluids) - Vit. C injections (unless there is UTI or CRF present, administered same way as B12) - Vit. E - Omega 3 (salmon oil) - Denosyl (if liver enzymes are elevated as well) - Pancreatic enzymes derived from animal pancreas not plants with every meal (my cat hated it and I had to syringe him immediately after every meal with a mixture of food, water and incubated enzymes - I thought it was essential that his pancreas gets a rest).
If your cat is still eating consider yourself lucky but don't count on it long term. Cats with pancreatitis get anorexic sooner rather than later. The medical solutions are not very good (assisted feeding, e-tube, appetite stimulants that make cats behave oddly). He should eat often (every 3 hours even at night) and small amounts (empty stomach and/or a lot of food at once tend to induce pain). Watch for symptoms of pain and give him food in the intervals, when he's physically able to eat. The attacks tend to wear off in 4-8 hours. Painkiller is your friend. Watch how rested he is after an attack that was helped with painkiller and how hard it is for him to bounce back when he didn't get it. He needs strength to fight pancreatitis. (Btw, I'm not sure if torbutrol comes in liquid version, buprenex, which is a similar drug does. You squirt it into the cheek pouch, the results are immediate. So you can actually wait until the attack starts and not give it on regular basis.)
L. acidophilus (probotic) shows some potential in helping soft stools. And try slippery elm bark powder, which should also help with some discomfort, diarrhea/soft stools and nausea.
My cat had his last attack in January and was battling the more acute version of the disease since September. And I'm not sure he's really over it yet. Be prepared: this may be long term. And yes, he's worth the trouble.
Good luck,
Alice
teri - 04 Mar 2006 19:48 GMT Hello.
>While pancreatic inflammation can be visible via ultrasound the only >way to diagnose it is to do PLI/TLI blood test (the turn-around is [quoted text clipped - 4 lines] >presents as an inflammation on abdominal ultrasound (you'll need biopsy >or at least laparoscopy to fully diagnose lymphoma). Lymphoma was thought to be the worst case scenario of his differential diagnoses when he had the ultrasound, but the Dr. who did the study found no evidence of any cancer and concluded that he had pancreatitis based on his findings.
>It's wrong to think that chronic pancreatitis resolves itself - it >does not. It's a chronic disease marked by returns of acute periods. >Once it presents itself, it always comes back. There is, at present, NO >treatment for it. From all the reading I have done I see that while it does not become cured, it does have to resolve itself and needs symptomatic, supportive treatment. But as you say, unfortunately no treatment for the inflammation itself.
>Another thing, if he's not getting better maybe you should consider >steroids? Seamus was initially suspected to have IBD, so he was given a week of prednisolone. That was started after only two weeks of him having symptoms of decreased activity (but still playing to a fair extent, just not as wild as his usual self), crouching at times, and having about half of each stool being very soft. After four days of the pred was when he then basically stopped playing altogether so we decided it was not IBD. He did then wean off the pred over the next week and a half.
>Other things you might want to consider before adding steroid therapy: >- Subcutaneous fluids (really easy to learn and very helpful) Would that be necessary would you think even if he is eating and drinking normally? There has been no change in the amount of pees daily between the two cats.
>- Denosyl (if liver enzymes are elevated as well) So far they have been wnl along with bile acid studies.
What is it meant by having attacks? Seamus never really seems to have any variation in how he feels other than more active about an hour to two after the torb is given, but never had vomiting, or any signs of worse pain than crouching and being quite which is what he has been doing for a month and a half now. Oh, at this past week's visit his dr. wanted to do the PLI test but he was not fasting so I took him in this morning to have that drawn.
I am going to start with the small frequent feedings, but every three hours is not going to work on weekdays. I will spread them out as much as possible though and continue to give the torb every 12 hours.
Thanks. Teri
Alice - 05 Mar 2006 17:21 GMT Hi Teri,
> Lymphoma was thought to be the worst case scenario of his differential > diagnoses when he had the ultrasound, but the Dr. who did the study > found no evidence of any cancer and concluded that he had pancreatitis > based on his findings. Same here... We opted out of biopsy because he wasn't a good candidate for chemo. The specialist who interpreted the ultrasound also didn't think it was cancer. But ultrasound cannot definitely eliminate lymphoma. Many times intestinal lymphoma does not develop any growths and the only way to find it is to take a sample and put it under the microscope. Some months later with no visible progression of the disease I'm more reassured that it's not lymphoma. (I'm very careful not to be too optimistic; this disease had so many setbacks...) Also, IBD and intestinal lymphoma present like identical twins on ultrasound. Did your internist see any evidence of IBD? Or was the inflammation contained to pancreas?
> Seamus was initially suspected to have IBD, so he was given a week of > prednisolone. That was started after only two weeks of him having [quoted text clipped - 4 lines] > was not IBD. He did then wean off the pred over the next week and a > half. Sounds like your cat had a bad reaction to pred, which is not unusual. Ask your vet about budesonide. It works differently than regular corticosteroids, has fewer side effects and is much better long term. It is the choice drug for IBD. (IBD not always responds to steroids, which makes things even more complicated.)
Have you tried a short course of antibiotics (metronidazole is prescribed most often)? If his pancreatitis is caused by infection it would make sense that it presented with soft stools only. If the infection is chronic wbc would not have to be elevated. It's worth trying, it's just not worth staying long term on it without visible improvement.
IBD is yet another disease that's very hard to diagnose. Also symptoms very much like pancreatitis. Also shows as an inflammation on ultrasound. My cat has it, I think. I suspected it for few years but the only proof I have so far is visible thickening of the intestinal walls on the ultrasound. Btw, if your internist didn't see IBD on ultrasound it doesn't necessarily mean it's not there. You might be fighting an early onset of it and the thickening of the intestine walls is not visible yet. (I know - this is hell.)
If I may make a suggestion: get rid of (if you haven't yet) foods that contains wheat gluten, wheat, soy, corn, etc., which are obvious allergens for cats. There are other good options on the market, sometimes even from the same brand your cat likes. (There is even dry food that doesn't contain any of it. I think, Innova Evo?) If it's IBD it might actually help his soft stools. If it's 'only' pancreatitis allergens won't stress his digestive track and that will help too.
> Would that be necessary would you think even if he is eating and > drinking normally? There has been no change in the amount of pees > daily between the two cats. Sub-q fluids for pancreatitis are not just saline solution. Lactated ringers solution is used instead, the same as IV fluids given to all post-op human patients. The objective is to infuse the body with electrolytes, minerals, so it could recover faster. A good analogy would be a tennis match between two same rank athletes, during the break when they are not dehydrated yet, one drinks Gatorade (lactated ringers) and the other water (saline) or nothing - who do you think is going to have more power in the next set? (A sub-q injection at the beginning of pain spell often helped me to shorten it by many hours simply because with fluids he could cope with pain.)
> What is it meant by having attacks? > Seamus never really seems to have any variation in how he feels other > than more active about an hour to two after the torb is given, but > never had vomiting, or any signs of worse pain than crouching and > being quite which is what he has been doing for a month and a half > now. In my cat's case the attacks would usually start with vomiting early in the morning, nausea (sometimes very severe) would continue thru the day and he could not eat; then it would all transform into pain that could last for hours. Sometimes I was able to manage the spell and end it sooner by giving him in short intervals all possible remedies I had on hand and by continuously offering food with enzymes. The indicators I watched for: sitting in a loaf position, hiding, sleeping or lying down when he should be up, not stretching while sleeping, disinterest, standing over the bowl with water and NOT drinking, sniffing food and NOT eating, eating grass, howling, lack of interest in his favorite foods even if I put it in front of him, lethargy, smacking his lips, unusually loud eating (the last two are clear indications of nausea). These indicators on any normal day could well be meaningless.
> I am going to start with the small frequent feedings, but every three > hours is not going to work on weekdays. Try putting food in many places, especially 'his' hiding places (a box he likes to sleep in, his favorite closet). In small places food smells more intensely and he might be tempted to try it more often. We also used to divide one 3 oz. can of food into 3 bowls. For some reason smaller portions seemed less intimidating than large ones. We kept 2 bowls of different foods next to his bed - if he wasn't feeling great he was probably lying down and if he suddenly felt slight inclination to eat - he didn't have far to go. Add a little water to can food - it will stay fresh longer. Wet food proved for us much better temptation. The other cat was of course tempted too so we had to separate them while we weren't home. Also, my husband used to call home and leave messages on our answering machine (we had to turn off our telco's voice mail). When hearing his voice the cat would come to the phone and sure enough next to the phone there was food too... There are many tricks.
I'm glad you managed to take the PLI test - the more you know at this point the better. Take care! Things will improve.
Alice
Alice - 05 Mar 2006 17:40 GMT Sorry, this is only to fix the subject title of the topic.
Alice
Phil P. - 06 Mar 2006 05:33 GMT > I am going to start with the small frequent feedings, but every three > hours is not going to work on weekdays. I don't think that's such a good idea. I've had the best results by spacing the feedings no less than 12 hours apart- gives the pancreas time to rest and heal between meals. Feeding stimulates pancreatic secretions which tend to aggravate the condition.
Alice - 07 Mar 2006 16:36 GMT Forgive me Phil but I strongly disagree. There are many reasons why feeding a cat with pancreatitis every 12 hours doesn't make sense to me:
1) Firstly, 97% of cats with pancreatitis show poor appetite and many loose a lot of weight during the entire course of the disease. Limiting their opportunity to eat to only 2x a day just doesn't make any sense.
2) Pancreatitis in cats is likely to cause diabetes (insuline is also produced by pancreas) or other nasty systemic disorders, including the infamous triad. About 60% of cases mark concurrent fatty change in the cats' livers. In older cats, i.e. the ones that tend to get chronic pancreatitis in the first place, it stresses kidneys enough to cause CRF (or increase CRF if the condition was preexisting). With these odds infrequent feeding (like twice a day), for obvious reasons, is really not a good idea!
3) Many vets say that steady supplementation of pancreatic enzymes is the key to success in fight against pancreatitis (pancreatic enzymes are associated with treatment of EPI but what is not commonly known is that it's also a very effective treatment to ease the extent of pancreatic secretions and pain in pancreatitis, i.e. you want to relieve the pancreas - here is your tool).
Usually, the dose is 1/4 tsp of enzymes per meal, which is 2.5-3 oz of wet food. Average cat eats about 8-9 oz of wet food a day. So, if you feed your cat twice a day (at least 4 oz of wet food per meal) then 1/4 tsp of enzymes is by definition too little (per meal) to matter. Larger single dose of viokase (trademark for animal source enzymes) is not advisable. In humans viokase has been known to cause burns in mouth and esophagus.
Hence, if you supplement viokase - as you should, you MUST feed the cat at least 3-4 times a day. And if you supplement it by gelcap (right after the meal, followed by water), which is a smaller dose than 1/4 tsp - you need to feed the cat more often than 4 times a day.
4) Finally all vets I asked, including a specialist from Madison School of Vet. Medicine and a feline nutritionist, told me that small, frequent meals of easily digestible, good quality food were the way to go. The same applies to human patients with chronic pancreatitis who are advised NOT to eat large meals _ever again_. And 4 oz IS a large meal for most cats (there is a reason why single meal can food contains no more than 3 oz). These days thinking is that large, infrequent meals are much more likely to aggravate pancreas into flooding itself with enzymes or spilling the enzymes into abdominal cavity than small, frequent meals could ever be.
>From my own experience I'll add that had I been advised to feed my cat every 12 hours and followed this ill advise despite his anorexia I have no doubt at all that he wouldn't've been alive today.
Alice
Phil P. - 07 Mar 2006 17:06 GMT > X-No-Archive:yes > > Forgive me Phil but I strongly disagree. That's ok, I don't mind.
This feeding plan has worked for me for many years with many cats that had pancreatis- providing, of course, they were not vomiting and still had an appetite-- which seems to be the case with Terri's cat. This is not a plan for all cats with pancreatitis.
You can't always rely on what you read, there is no one ideal treatment for all cats with pancreatitis. The treatment plan must be designed specifically for each individual cat.
I'm pleased that your plan worked for your cat.
Phil
Rhonda - 04 Mar 2006 15:36 GMT Hi Teri,
Sorry your cat is not feeling so well. Our cat, Bob, also had chronic pancreatitus. I'll tell you some of his story to see if it helps.
His started six months after his diabetes diagnosis (which happened right after a steroid shot for allergies...)
Bob would throw up, have diarrhea, a high fever and just be listless. He was in pain and would yowl if we picked him up. During his first six months after diagnosis, he probably had about three major attacks that sent him to the hospital, some for a week at a time. He was always treated by an internist vet, a specialist. He was on an IV and his fever watched carefully. He usually had to be force fed. The internist said anti-nausea drugs do not work with cats. The treatment was basically supportive care to get him through the episode. They also always sent him home with metronidizole (sp?).
The vet said once a cat has pancreatitus, it changes the lining inside of the pancreas which is why it often becomes a chronic problem. She also said that the way to treat it in dogs is to fast them and rest the pancreas. Because of the way cats are built, they cannot be fasted without possible liver damage -- so treating it gets more complicated.
At the end of that six months, we were frazzled and a few thousand dollars shorter. At Christmas, we found Bob again in pain and we didn't know what to do. My sig. other thought maybe it was time to let him go because this was no way to live, but I told him I could not think of letting Bob go yet. We took him to the hospital again, he got better and voila! No more attacks for a year!
Bob had a wonderful, pain-free year, relaxing on his window. I told you all of this because watching your cat go through such pain can be harrowing, plus the expense and the vet trips -- but they can have long periods of a wonderful life.
In case you're wondering, Bob died that next year of cancer. It was not related to his pancreas problems.
Good luck with your cat,
Rhonda
> Does anyone have experience with chronic feline pancreatitis? > Seamus was diagnosed by ultrasound Feb 1, and has been on torbutrol [quoted text clipped - 7 lines] > about keeping him on the opoid that long. When will he feel better? > Teri teri - 04 Mar 2006 19:58 GMT Rhonda,
>Sorry your cat is not feeling so well. Our cat, Bob, also had chronic >pancreatitus. I'll tell you some of his story to see if it helps. Thank you for your thoughts and for telling my Bob's story. I am happy for you that he did have that good year on his window after all he was throught, and I am very sorry for your loss at that point. This is hard, and you, along with some new friends have given me encouragement that is much needed. I go thru days where I just feel so depressed about him, and others where I am sure this period will end soon and he will be himself again. I realize that he most likely will have relapses and while the doctor is talking to me about that all I can think of is that he needs to feel better first before we worry about that. So I continue reading and re-reading articles, asking questions, and working with what I learn along the way. Thank you. Teri
yngver - 06 Mar 2006 16:19 GMT > Rhonda, > [quoted text clipped - 14 lines] > Thank you. > Teri Teri, try not to be too depressed. After reading these stories I suppose what our cat had was acute mild pancreatitis and not chronic, but she had it more than two years ago, recovered completely and so far it hasn't happened again. Of course, although the pancreatic enzyme assay was indicative of pancreatitis the vet could still not be 100 percent sure that's what she had, so maybe it was some kind of infection that mimicked pancreatitis. But my point is that you don't know for sure that your cat will have relapses once he recovers. Since he is eating and drinking normally I'd take that as a good sign. Good luck to you. -Yngver
teri - 13 Mar 2006 00:26 GMT The results on my cat's PLI have come back - 3.3. WNL. That would be great if he were looking better. To recap: He has been showing what to me looks like signs of abdominal pain. He doesn't play or run around the house,he sits around hunching down much of the time. That is his only symptom. Other than that he is eating great, no vomiting, occasional soft stool, no diarrhea, no weight loss. Palpating his abdomen seems ok, no crying or fighting with that. He had an abdominal ultrasound Feb. 1 that showed a very inflammed pancreas which is where the diagnosis of pancreaitis came from, and a smaller liver. Liver studies have all been normal including bile acid studies. Dr.s concluded that is just normal for him. He has been on Torbutrol since Feb. 1 which does help him and make him look more comfortable - plays, doesn't hunch down as much. He still needs the torb, but he is down to a quarter of a tablet BID which is down from a half. Just started on Metronidazole, thinking IBD could be causing the abdominal pain signs. He has been in Hill's ID since mid January.
Any other ideas on why he doesn't feel better despite a normal PLI? Teri
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