take he cat carrier leave it out for him to get used to   in a day or two
put his food in the cat carrier so he trust the cat carrier.   Take him for
a drive a couple of times if you have time.  Get him used to the idea ok we
go in car it ok.  Make sure you have his favorite treats for him and give
him lots of love.  If you got a big vehicle  rent or buy a large dog cage
and put a littler box in it  so he has room to maneuver you don't want a
furball wandering  all over the car

Plenty of stops for food, water, etc and sedatives from the vet.

Try to make as few stops as possible.  Every time you stop and start its
like another trip.  Also, try to face the front of the carrier away from the
window so the cat can't see the background whizzing by- cats find the motion
unsettling, so, the less they see, the better.  You also might want to spray
the carrier with Feliway an hour or two before you begin the trip- might
help to calm him down a bit.

Phil

I have done this several times.

I remove the food and water access the night before the trip. If the
trip is longer than 7 - 8 hours you might want to consider stopping for
a water and food break.

In the morning before placing in the carrier, I encourage use of the
litter box. If they don't, that's fine. I just don't want them in the
carrier without having had the opportunity to use the litter box first.

The carrier used is big enough for the cat to stand up in and turn
around and if they do make a mess inside they don't have to sit in it.

I also try to make the carrier as level as possible inside the vehicle.
If you have a vehicle with enough floor space to put the carrier on this
won't be an issue; however, a carrier inside a car on the seat is not level.

Depending on the cat, you might want to try a blanket over the carrier
to block out the movement going on and encourage quiet time... but if
your cat wants to see you and is reassured by that then this won't work.

Chose a route to your destination that is the straightest smoothest road
you can find. I have found with my cat that twisty roads causes her to
be sick. Don't make any unnecessary stops. Obviously for safety reasons
you should be stopping once in a while to get out from behind the wheel
to stretch and give yourself a break.

Once we arrive, the cat is the first priority. The cat is released from
the carrier asap and are shown where the food, water and litter box is.

There was a time when I was doing a regular 8 hour trip almost every
weekend with 2 cats. One was an excellent traveller, but was disoriented
for a couple of days at the destination despite having been there
before. The other wasn't such a good traveller usually getting sick
(throwing up) along the way, but adapted like a fish to water at the
destination. It was then that I discovered my twisty route that shaved
50 miles off the trip was causing the sickness when I tried the better
but longer route one weekend.

fuckem

makem do what you need.
they are creatures of adaption
don't hate me because of my words
when they see the greater purpose they will say

"it was good for me to have travelled

do what you gotta do
cats are secondary

cause if you don't eat nobody eats

you making that money?

dont forget to make that money

jules <jm2545@yahoo.com> wrote in rec.pets.cats.health+behav:

Kami squawks all the way to the vet, too, but after two two-day, 10-
hour each interstate car trips, I found that as long as she was
positioned so she could see out, she shut up after about an hour...  
Then, periodically, she asked for water or the litter box.  She was
amazingly good, thank god and bless her heart.