 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
| HomeDiscussion GroupsGeneral TopicsCat AnecdotesHealth and BehaviorRescue CatKB.com Contact UsLink To UsSearch & Site Map |
Cat Forum / Health and Behavior / February 2004Ping: Mary, Phil
RE: msg-id:Xl7Xb.3972$%d3.541933@twister.southeast.rr.com I can't get back the original message in Xnews and had to look it up in google. I'm glad you guys had this discussion because I'm going to talk to Shadow's vet tomorrow when I take him for his shave and squeeze and ask about switching him to 10mg EOD instead of the 5 per day he is on. I had NO idea. Thank you. I hate the pred. He just is enormous. Not just from gaining weight, but his head is big. A friend of mine was recently sick and had to be treated with high doses of prednisone to kill an infection and he said he bloated up to 220 pounds and he's a small guy. He said his face was mooshed and it reminds me of Shadow.  SignatureCheryl Trapped like rats. In a chia-pet. MIB II > RE: msg-id:Xl7Xb.3972$%d3.541933@twister.southeast.rr.com > [quoted text clipped - 7 lines] > said he bloated up to 220 pounds and he's a small guy. He said his face > was mooshed and it reminds me of Shadow. I nearly died after a near-drowning incident, and was put on high doses of pred for 9 months - gained 60 lbs almost immediately. It was the weirdest thing in the world - didn't really eat differently, the drugs just *completely* changed my body chemistry. Many purrs to poor Shadow. The bad thing about pred is that you feel so good on it, and so crappy off of it... -L. > RE: msg-id:Xl7Xb.3972$%d3.541933@twister.southeast.rr.com > [quoted text clipped - 7 lines] > said he bloated up to 220 pounds and he's a small guy. He said his face > was mooshed and it reminds me of Shadow. Let us know what the vet says. I've seen this sort of swelling in people on steroids but not cats. I'll be thinking about you two. > RE: msg-id:Xl7Xb.3972$%d3.541933@twister.southeast.rr.com > [quoted text clipped - 7 lines] > said he bloated up to 220 pounds and he's a small guy. He said his face > was mooshed and it reminds me of Shadow. Facial swelling is one of the possible adverse effects -- the increase of extracellular fluid volume might be a contributing factor in the puffy look but weight gain is probably more common -- and not in a good way. Glucocorticoids convert body protein (muscle) into glucose. But even though steroids cause muscle wasting and thinning skin, gluconeogenesis and glycogen synthesis and increases in both lipolysis and lipogenesis produce a net increase in body fat so the cat actually gains weight while simultaneously losing muscle mass. E.O.D. dosing minimizes this`effect, but you still should keep an eye out for muscle atrophy. Just a reminder: If you're switching to e.o.d. therapy, remember, you should use *only* the *short-acting* steroids (12-36 hr). If you use the longer acting forms, the doses will *overlap* and you'll lose all the benefits of e.o.d. Good luck. Phil > Just a reminder: If you're switching to e.o.d. therapy, remember, you > should use *only* the *short-acting* steroids (12-36 hr). If you use the > longer acting forms, the doses will *overlap* and you'll lose all the > benefits of e.o.d. She said that she rarely sees side effects of prednisone in cats. Weight gain, yes. Diabetes if the cat is already a candidate (pre-diabetic?) She agreed that of course EOD is the way to go but some cats have flare-ups when messing with pred. I am going to try EOD, but I have a question. If short-acting steroids (and I did a little research, and prednisone in the 5mg dose he gets is considered short-acting (biologic life 12-36 hours) don't remain in the body over that amount of time, isn't 10mg every other day as opposed to the 5mg daily overkill? If 5 helps him and 10 doesn't remain in his system over the 2 day period, what is the point of doubling the dose EOD? I remember in the past trying to cut back and give him 5mg EOD and he went back to vomiting. I ordered him bloodwork and will find out the results of those tomorrow, but his vet wasn't so open and I may be reading her body language when I asked, but she seemed hesitant to me. I mean, if pred is the only thing that gives him relief and it comes back that he is now diabetic, or worse, what is the answer? Cut out the pred and treat diabetes? Diet isn't helping his IBD even though he is mostly on canned food. I can't get him to eat the foods that are better quality so in his case the canned he'll eat is better than the dry he will scarf if I were to let him? He won't eat a steady diet of home made. He's just so freaking hungry all the time and at least he didn't gain any weight since the last time he was in. Still holding at 20 lbs. > > Just a reminder: If you're switching to e.o.d. therapy, remember, > you [quoted text clipped - 7 lines] > Weight gain, yes. Diabetes if the cat is already a candidate > (pre-diabetic?) HPA supression is the concern. E.O.D. minimizes and in many cases, eliminates it. She agreed that of course EOD is the way to go but > some cats have flare-ups when messing with pred. I am going to try > EOD, but I have a question. If short-acting steroids (and I did a [quoted text clipped - 3 lines] > daily overkill? If 5 helps him and 10 doesn't remain in his system > over the 2 day period, what is the point of doubling the dose EOD? Better suppression of symptoms - takes longer for the symptoms to recur. If the cat responds well to e.o.d., you can try every third and sometimes, even every fouth day dosing - I've never had much luck with every fouth day dosing unless the symptoms resolved or the disease went into remission. But I did get lucky a few times with every third day dosing. Another important benefit of e.o.d. is the cat is less likely to develop steroid tachyphylaxis. I > remember in the past trying to cut back and give him 5mg EOD and he > went back to vomiting. That's because you were cutting the dose in half. > I ordered him bloodwork and will find out the results of those > tomorrow, but his vet wasn't so open and I may be reading her body > language when I asked, but she seemed hesitant to me. I mean, if pred > is the only thing that gives him relief and it comes back that he is > now diabetic, or worse, what is the answer? Cut out the pred and > treat diabetes? It may not be true diabetes. Glucocorticoids convert protein into glucose and also stimulates gluconeogenesis (forms glucose from the glycerol in fats). You may have to treat both - which isn't as bad as it sounds. Diet isn't helping his IBD even though he is mostly > on canned food. I can't get him to eat the foods that are better > quality so in his case the canned he'll eat is better than the dry he > will scarf if I were to let him? He won't eat a steady diet of home > made. He's just so freaking hungry all the time and at least he > didn't gain any weight since the last time he was in. Still holding > at 20 lbs. . Could be the prednisone - its also an appetite stimulant. 2004: >> > benefits of e.o.d. >> > [quoted text clipped - 4 lines] > HPA supression is the concern. E.O.D. minimizes and in many cases, > eliminates it. Well, I'm going to try again with EOD and see how he does. Tonight is an off-night, in fact I already started it when I posted to you originally, so he had 10 sat, none sun, 10 last night and none today. He seems a little "groany" but he's eating ok. Might not work out. > If 5 helps him and 10 doesn't remain in his >> system over the 2 day period, what is the point of doubling the dose [quoted text clipped - 6 lines] > disease went into remission. But I did get lucky a few times with > every third day dosing. That would be wonderful if it works. > Another important benefit of e.o.d. is the cat is less likely to > develop steroid tachyphylaxis. [quoted text clipped - 4 lines] > > That's because you were cutting the dose in half. Ok. <more snip> > It may not be true diabetes. Glucocorticoids convert protein into > glucose and also stimulates gluconeogenesis (forms glucose from the > glycerol in fats). You may have to treat both - which isn't as bad as > it sounds. His blood work was good. I got a call from his vet today on my machine and I can't get a copy faxed to me until I'm back in the office Friday. I'm very relieved since he's been on the daily pred for over a year and a half. At least he doesn't seem to have any other issues. For now. :) SignatureCheryl Trapped like rats. In a chia-pet. MIB II
|
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.