Yes.  My cat of indeterminate age (abandoned by the neighbors) developed a
vaccine related sarcoma on her right hind leg.  I caught it late, and made
the mistake of allowing the regular vet (who told me to my face they didn't
"believe" in vaccine related sarcomas) to try to remove it.

It was too entwined in the nerves and tendons.  I took her to U Penn where
they took off her leg and hip.

She did very well.  She succumbed less than a year later to possible latent
FIP, but the true cause was unknown.  It was unlikely her death was related
to
the sarcoma, as they do not usually metastasize.

If your cat is a candidate for surgery (strong heart, good kidneys & liver)
then I'd go to a teaching hospital to have it done.  It can be a very
successful surgery, and cats are reported to do very well on 3 legs.  Mine
did just fine, even learned to run!

Good luck and best wishes to you & kitty.