Cat Forum / Cat Anecdotes / May 2005
OT: Purrs for Kylie
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Adrian - 17 May 2005 18:00 GMT I'm not a particular fan of Kylie Minogue, but I was very sorry to hear the news, she has breast cancer. On the day of Christina's surgery it made me think how unfair this disease is.
 Signature Adrian (Owned by Snoopy & Bagheera) A house is not a home, without a cat.
Howard Berkowitz - 17 May 2005 18:42 GMT > I'm not a particular fan of Kylie Minogue, but I was very sorry to hear > the news, she has breast cancer. On the day of Christina's surgery it > made me think how unfair this disease is. In the last 12 months or so, several large clinical trials have had spectacular results with several improvements in treatment. Clinical trials are monitored by an independent safety board, which can stop them under two circumstances. The more common, unfortunately, is that the experimental treatment is dangerous. The "hole in one", however, is when the board determines that the experimental treatment is so superior to standard treatment that it would be unethical not to give it to the patients assigned to standard treatment [1].
There were two such trials stopped because the aromatase inhibitors with which they were experimenting were much superior to tamoxifen, which was considered a major breakthrough not all that long ago. The studies now are to determine the guidelines of which of the two approved new drugs are better for specific patients, and also if they should be combined with tamoxifen.
Other trials have shown that a different mixture of low-dose chemotherapy drugs right after surgery is MUCH better in being sure the disease is gone.
Physicians involved are hesitant to use the "cure" word, but more and more are telling patients that they will probably die of something other than breast cancer.
[1] In the past, the control arm of a trial received placebo. That is now considered unethical, if there is a known treatment for the disease. The control patients get the best current treatment while the others get the experimental treatment. During the trial, the patients and the clinicians do not know which drug the patients receive, but the safety board has that information.
Monique Y. Mudama - 17 May 2005 22:27 GMT > [1] In the past, the control arm of a trial received placebo. That > is now considered unethical, if there is a known treatment for the > disease. The control patients get the best current treatment while > the others get the experimental treatment. During the trial, the > patients and the clinicians do not know which drug the patients > receive, but the safety board has that information. I didn't know this. It makes sense, doesn't it?
 Signature monique, who spoils Oscar unmercifully
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Howard Berkowitz - 17 May 2005 22:48 GMT > > [1] In the past, the control arm of a trial received placebo. That > > is now considered unethical, if there is a known treatment for the [quoted text clipped - 4 lines] > > I didn't know this. It makes sense, doesn't it? It's relatively recent. Patients with serious diseases were understandably reluctant to enroll in a trial when they might not get anything except placebo.
If there is no accepted treatment for a disease, giving a placebo and supportive treatment is still considered ethical.
Clinical trial design can get quite complex. If the treatment is for a condition that is not life-threatening, there is another statistical technique called double-blind crossover. This effectively rules out any "placebo effect." The standard and experimental treatments are made up as pills, solutions or injection, etc., which look identical. In a crossover study, at some point the patients on the experimental treatment change to the established one, and vice versa. If the benefit observed in the patient changes, that's fairly strong evidence that the treatment they were receiving actually was doing (or not doing) something. In a double-blind randomized crossover trial, neither the patients nor the clinicians know when and if the switch will take place.
Karen - 17 May 2005 18:56 GMT I heard about this girl. I don't know her and was wondering what her name is. SHe sounds very confident that they have caught it early. She looks extremely young to have breast cancer (not unheard of but unusual).
> I'm not a particular fan of Kylie Minogue, but I was very sorry to hear > the news, she has breast cancer. On the day of Christina's surgery it > made me think how unfair this disease is. Yowie - 18 May 2005 13:50 GMT Kylie Minogue is my age - 36 this year. Kylie is a huge popstar from Australia and is popular here in Australia and even more huge in England. I don't know if she is big in the rest of Europe, but she obviously hasn't broken into the USA market allt hat much yet. Before she became a singer, she starred in Neighbours, the longest running soapy *ever* (AFAIK) which is from Australia (it started when I was in highschool) and also very popular in the UK.
Her sister, Dannii Minogue is also a pop star (although to a lesser degree) and their father is an actor here in Australia.
Yowie
>I heard about this girl. I don't know her and was wondering what her name > is. SHe sounds very confident that they have caught it early. She looks [quoted text clipped - 3 lines] >> the news, she has breast cancer. On the day of Christina's surgery it >> made me think how unfair this disease is. Howard Berkowitz - 18 May 2005 16:20 GMT > Kylie Minogue is my age - 36 this year. Kylie is a huge popstar from > Australia and is popular here in Australia and even more huge in England. [quoted text clipped - 6 lines] > popular > in the UK. I'm generally oblivious to popstars, so I simply noted "some sort of celebrity", since I vaguely recognized the name. "Celebrity" has become more and more of a weird concept in North America, where people are famous simply because they are famous.
The Japanese equivalent, "talento", at least implies the celebrity can do something. Apparently, Kylie Minogue can do several entertainment things, and we certainly can send purrs.
I _think_ Paris Hilton is actually aware that her image is a caricature, and laughs at herself. There was a picture of her a day or so ago in the Washington Post, where she is the spokesman for some fast-food chain. She's shown eating a presumably large and greasy hamburger, wearing a dress with cutout sides and midriff, showing abdominal definition generally incompatible with large and greasy hamburgers. The company -- I really can't think of the name -- says they will feature her in a 30 second commercial, but have a "more provocative" 60 second version on their website.
Rhonda, on her back, loudly demanding a belly rub, I think presents the image somewhat better.
Cathi - 18 May 2005 18:33 GMT >Kylie Minogue is my age - 36 this year. Kylie is a huge popstar from >Australia and is popular here in Australia and even more huge in England. I [quoted text clipped - 6 lines] >Her sister, Dannii Minogue is also a pop star (although to a lesser degree) >and their father is an actor here in Australia. I didn't know about their father being an actor. Dannii has of course also had an acting career - another of the Australian tea-time soaps, but I can't remember which one. Something about Summer Bay?
What amazes me is the length of Kylie's career. Her early hits were all very "poppy", designed to appeal to pre-teen girls, and I personally thought she was just a flash in the pan. But over the years she's changed both musical and personal style a number of times, mostly with a reasonable amount of success here in the UK (major hits were a bit thin on the ground in the Nineties). Who'd have imagined that sweet little girl singing a song from the perspective of a murder victim who's killed by her lover?!
 Signature Cathi
polonca12000 - 19 May 2005 21:01 GMT Lots of purrs and best wishes for her to recover completely,
 Signature Polonca & Soncek
> I'm not a particular fan of Kylie Minogue, but I was very sorry to hear > the news, she has breast cancer. On the day of Christina's surgery it > made me think how unfair this disease is.
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