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OT: Purrs for Kylie

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Adrian - 17 May 2005 18:00 GMT
I'm not a particular fan of Kylie Minogue, but I was very sorry to hear
the news, she has breast cancer. On the day of Christina's surgery it
made me think how unfair this disease is.
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Adrian (Owned by Snoopy & Bagheera)
A house is not a home, without a cat.

Howard Berkowitz - 17 May 2005 18:42 GMT
> I'm not a particular fan of Kylie Minogue, but I was very sorry to hear
> the news, she has breast cancer. On the day of Christina's surgery it
> made me think how unfair this disease is.

In the last 12 months or so, several large clinical trials have had
spectacular results with several improvements in treatment.  Clinical
trials are monitored by an independent safety board, which can stop them
under two circumstances. The more common, unfortunately, is that the
experimental treatment is dangerous.  The "hole in one", however, is
when the board determines that the experimental treatment is so superior
to standard treatment that it would be unethical not to give it to the
patients assigned to standard treatment [1].

There were two such trials stopped because the aromatase inhibitors with
which they were experimenting were much superior to tamoxifen, which was
considered a major breakthrough not all that long ago. The studies now
are to determine the guidelines of which of the two approved new drugs
are better for specific patients, and also if they should be combined
with tamoxifen.

Other trials have shown that a different mixture of low-dose
chemotherapy drugs right after surgery is MUCH better in being sure the
disease is gone.

Physicians involved are hesitant to use the "cure" word, but more and
more are telling patients that they will probably die of something other
than breast cancer.

[1] In the past, the control arm of a trial received placebo.  That is
   now considered unethical, if there is a known treatment for the
   disease.  The control patients get the best current treatment
   while the others get the experimental treatment.  During the trial,
   the patients and the clinicians do not know which drug the patients
   receive, but the safety board has that information.
Monique Y. Mudama - 17 May 2005 22:27 GMT
> [1] In the past, the control arm of a trial received placebo.  That
> is now considered unethical, if there is a known treatment for the
> disease.  The control patients get the best current treatment while
> the others get the experimental treatment.  During the trial, the
> patients and the clinicians do not know which drug the patients
> receive, but the safety board has that information.

I didn't know this.  It makes sense, doesn't it?

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monique, who spoils Oscar unmercifully

pictures: http://www.bounceswoosh.org/rpca

Howard Berkowitz - 17 May 2005 22:48 GMT
> > [1] In the past, the control arm of a trial received placebo.  That
> > is now considered unethical, if there is a known treatment for the
[quoted text clipped - 4 lines]
>
> I didn't know this.  It makes sense, doesn't it?

It's relatively recent. Patients with serious diseases were
understandably reluctant to enroll in a trial when they might not get
anything except placebo.

If there is no accepted treatment for a disease, giving a placebo and
supportive treatment is still considered ethical.

Clinical trial design can get quite complex. If the treatment is for a
condition that is not life-threatening, there is another statistical
technique called double-blind crossover. This effectively rules out any
"placebo effect."  The standard and experimental treatments are made up
as pills, solutions or injection, etc., which look identical. In a
crossover study, at some point the patients on the experimental
treatment change to the established one, and vice versa.  If the benefit
observed in the patient changes, that's fairly strong evidence that the
treatment they were receiving actually was doing (or not doing)
something. In a double-blind randomized crossover trial, neither the
patients nor the clinicians know when and if the switch will take place.
Karen - 17 May 2005 18:56 GMT
I heard about this girl. I don't know her and was wondering what her name
is. SHe sounds very confident that they have caught it early. She looks
extremely young to have breast cancer (not unheard of but unusual).

> I'm not a particular fan of Kylie Minogue, but I was very sorry to hear
> the news, she has breast cancer. On the day of Christina's surgery it
> made me think how unfair this disease is.
Yowie - 18 May 2005 13:50 GMT
Kylie Minogue is my age - 36 this year. Kylie is a huge popstar from
Australia and is popular here in Australia and even more huge in England. I
don't know if she is big in the rest of Europe, but she obviously hasn't
broken into the USA market allt hat much yet. Before she became a singer,
she starred in Neighbours, the longest running soapy *ever* (AFAIK) which is
from Australia (it started when I was in highschool) and also very popular
in the UK.

Her sister, Dannii Minogue is also a pop star (although to a lesser degree)
and their father is an actor here in Australia.

Yowie

>I heard about this girl. I don't know her and was wondering what her name
> is. SHe sounds very confident that they have caught it early. She looks
[quoted text clipped - 3 lines]
>> the news, she has breast cancer. On the day of Christina's surgery it
>> made me think how unfair this disease is.
Howard Berkowitz - 18 May 2005 16:20 GMT
> Kylie Minogue is my age - 36 this year. Kylie is a huge popstar from
> Australia and is popular here in Australia and even more huge in England.
[quoted text clipped - 6 lines]
> popular
> in the UK.

I'm generally oblivious to popstars, so I simply noted "some sort of
celebrity", since I vaguely recognized the name. "Celebrity" has become
more and more of a weird concept in North America, where people are
famous simply because they are famous.

The Japanese equivalent, "talento", at least implies the celebrity can
do something. Apparently, Kylie Minogue can do several entertainment
things, and we certainly can send purrs.

I _think_ Paris Hilton is actually aware that her image is a caricature,
and laughs at herself. There was a picture of her a day or so ago in the
Washington Post, where she is the spokesman for some fast-food chain.  
She's shown eating a presumably large and greasy hamburger, wearing a
dress with cutout sides and midriff, showing abdominal definition
generally incompatible with large and greasy hamburgers. The company --
I really can't think of the name -- says they will feature her in a 30
second commercial, but have a "more provocative" 60 second version on
their website.

Rhonda, on her back, loudly demanding a belly rub, I think presents the
image somewhat better.
Cathi - 18 May 2005 18:33 GMT
>Kylie Minogue is my age - 36 this year. Kylie is a huge popstar from
>Australia and is popular here in Australia and even more huge in England. I
[quoted text clipped - 6 lines]
>Her sister, Dannii Minogue is also a pop star (although to a lesser degree)
>and their father is an actor here in Australia.

I didn't know about their father being an actor.  Dannii has of course
also had an acting career - another of the Australian tea-time soaps,
but I can't remember which one.  Something about Summer Bay?

What amazes me is the length of Kylie's career.  Her early hits were all
very "poppy", designed to appeal to pre-teen girls, and I personally
thought she was just a flash in the pan.  But over the years she's
changed both musical and personal style a number of times, mostly with a
reasonable amount of success here in the UK (major hits were a bit thin
on the ground in the Nineties).  Who'd have imagined that sweet little
girl singing a song from the perspective of a murder victim who's killed
by her lover?!
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Cathi

polonca12000 - 19 May 2005 21:01 GMT
Lots of purrs and best wishes for her to recover completely,
Signature

Polonca & Soncek

> I'm not a particular fan of Kylie Minogue, but I was very sorry to hear
> the news, she has breast cancer. On the day of Christina's surgery it
> made me think how unfair this disease is.
 
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